Breast Cancer
Estrogen influences vascular endothelial growth factor in a biphasic manner
Published in Cancer Weekly, April 8th, 2003
According to recent research from the United States, "estrogens have been shown to regulate vascular endothelial growth factor-A (VEGF-A) for physiological and patho-physiological functions. However, estrogen action on VEGF-A mRNA expression has not been completely elucidated."
"We have identified two phases of activation of VEGF-A mRNA transcription, one early and one late response, induced by 17beta-estradiol (17beta-E-2) in ER+ MCF-7 breast tumor cells, depending upon the length of exposure," commented K. Sengupta and colleagues, Veterans Administration Med Center,...
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Source: Cancer Weekly (2003-04-08)
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