Biomarkers
Several genes may be reliable markers for primary liver cancer
Published in Cancer Weekly, April 8th, 2003
"Hepatocellular carcinoma (HCC) is a common primary cancer associated frequently with hepatitis C virus (HCV). To gain insight into the molecular mechanisms of hepatocarcinogenesis, and to identify potential HCC markers, we performed cDNA microarray analysis on surgical liver samples from 20 HCV-infected patients. RNA from individual tumors was compared with RNA isolated from adjacent nontumor tissue that was cirrhotic in all of the cases," researchers in the United States reported.
"Gene expression changes related to cirrhosis were filtered out using experiments in which pooled RNA...
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Source: Cancer Weekly (2003-04-08)
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