Cancer Vaccine

Rapid generation of antigen-presenting cells from leukemic blasts developed

Published in Cancer Weekly, April 8th, 2003

A method for the rapid generation of antigen-presenting cells from leukemic blasts in acute myeloid leukemia has been developed.

"The ability of acute myeloid leukemia (AML) cells to acquire dendritic cell (DC)-like characteristics in vitro with a rapid culture method based either on the phorbol ester PMA or calcium ionophores has been studied in comparison to conventional AML-DC cultures with the cytokines granulocyte-macrophage colony-stimulating factor (GM-CSF), tumor necrosis factor-alpha (TNF-alpha), interleukin-3 (IL-3), SCF, FLT3-L, and IL-4. In all AML patients, antigen-presenting cells (APC) could be generated from leukemic cells in two days by incubation with...

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Source: Cancer Weekly (2003-04-08)

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