Cervical Cancer
The E2/E6 gene ratio in papillomavirus-16 cancer can help diagnose stage
Published in Cancer Weekly, April 8th, 2003
According to a study from Poland, "Integration of human papillomavirus (HPV) DNA into host genome occurs early in cancer development and is probably an important event in malignant transformation of cervical cancer. The HPV genome integration usually disrupts E2 gene open reading frames. It results in the lack of E2 gene suppressor of the synthesis of E6 and E7 products which, in turn, leads to the overexpression of E6 and E7 genes."
"The oncogenic HPV types (HPVs 16, 18, 45, and 58) can be present as episomes or may integrate into human chromosomes. Sixty-six cervical...
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Source: Cancer Weekly (2003-04-08)
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