Tumor Progression
Researchers discuss novel insights into cadherin processing
Published in Cancer Weekly, April 15th, 2003
"Proprotein convertases (PCs) are known to activate many important molecules and their overexpression plays a significant role in tumor progression," researchers in Switzerland report.
"Only little is known about the involvement of PCs in the processing of cadherin adhesion molecules, which are potent tumor suppressors. Here we show in a baculovirus overexpression system that the desmosomal cadherins Dsg1 and Dsg3 are substrates for the PC furin," wrote H. Posthaus and colleagues, University of Bern, Institute of Animal Pathology.
"Accordingly, inhibition of PCs in...
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Source: Cancer Weekly (2003-04-15)
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