Carcinogenesis
Lymphoid enhancer factor 1 makes cells resistant to transforming growth factor
Published in Cancer Weekly, April 15th, 2003
"The activation of lymphoid enhancer factor (LEF)/T-cell factor (TCF)-mediated transcription by sustained expression of beta-catenin and the loss of transforming growth factor beta (TGF-beta) signaling are essential steps in carcinogenesis, particularly for cancers of the colon, breast, and liver," researchers in Japan report.
"The oncogene c-myc is a common target of both of these signaling pathways and a key regulator of cell cycle progression. Here we have identified a novel LEF/TCF-responsive element in the promoter of the human c-myc gene. Beta-catenin activated...
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Source: Cancer Weekly (2003-04-15)
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