Cellular Growth
The protein, PRH, is a tissue-specific inhibitor of elF4E in myeloid cells
Published in Cancer Weekly, April 15th, 2003
According to recent research from the United States, "The translation initiation factor eIF4E is involved in the modulation of cellular growth. In the nucleus, where eIF4E is associated with PML nuclear bodies, eIF4E mediates nucleocytoplasmic transport of specific transcripts, and this contributes to its transformation activity.
"Surprisingly, we found that a transcription factor, the proline-rich homeodomain protein PRH, is a negative regulator of eIF4E in myeloid cells, interacting with eIF4E through a conserved binding site typically found in translational regulators,"...
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Source: Cancer Weekly (2003-04-15)
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