Cancer Weekly

Cancer Metastasis - Interleukin-1 is a prerequisite for tumor invasion and angiogenesis

Gene Detection - Dual "molecular beacons" might eventually lead to very early cancer diagnosis

Antiangiogenesis - A new hypoxia-dependent agent inhibits tumor-specific neovascularization

Bladder Cancer - Hexvix cystoscopy improves treatment of patients - new phase III results

Body Mass Index - Height, but not weight or BMI, associated increases risk of testicular cancer

Liver Cancer - Researchers probe promising treatment

Sciatic Nerve Tumor - EMG and MRI used to diagnose sciatic nerve tumor in two dogs

Anal Cancer - Shorter irradiation and added mitomycin C are now standard EORTC therapy

Antiangiogenesis - Tissue inhibitor of metalloproteinase-3 limits angiogenesis and neuroblastoma

Anticancer Gene - FHIT induced apoptosis of cancer cells is limited by substrate binding

Antimetastatic Enzyme - Nucleoside diphosphate kinase/NM23 regulates aspects of tumor metastasis

Antioxidant Activity - Liposome assay shows total activity of fruits and vegetables varies tremendously

Antitumor Activity - Agonistic antibodies to CD40 and IL-2 induce dendritic and CD8+ cell activity

Antitumor Agents - Researchers develop potential antitumor agents that inhibit histone deacetylase

Apoptosis - Transcription of PAC1 directly regulated by p53

Appointments - TergeGen names VP of R&D and chief scientific officer

Bladder Cancer - Diagnostics by MRI are comparable with conventional and CT cystoscopy

Bladder Carcinoma - Transitional cell carcinoma presents as a rare case of extensive skin metastases

Bone Metastasis - Severe hypocalcemia can follow a single pamidronate injection

Brain Cancer - Dose components determined for boron neutron capture therapy

Breast Cancer - Analysis of breast cell membranes reveals many undiscovered proteins

Breast Cancer - Core biopsy without image guidance for palpable lumps key due to sensitivity

Breast Cancer - Israeli team uncovers protein responsible for metastases

Breast Cancer - NCI study estimates more than 2 million women could benefit from tamoxifen

Breast Cancer - The offspring's or father's genotypes may predict mother's breast cancer risk

Breast Cancer - The ortholog of BRCA1 is identified in Arabidopsis thaliana

Breast Cancer - The potency of oral contraceptives influences risk among younger women

Breast Cancer - Variants of XRCC1 and XRCC3 genes may contribute to breast cancer susceptibility

Breast Cancer - iCAD introduces software for use with full field digital mammography systems

Breast Cancer Epidemiology - Marin rates exaggerated by faulty data

CNS Tumors - High ¹²³I-IMP is seen on SPECT image in primary CNS lymphoma

Cancer Gene Therapy - Timing is crucial for HSV-1 thymidine kinase/ganciclovir-mediated cytotoxicity

Cancer Immunology - Specific antitumor antibody patterns exist in sera of patients with lung cancer

Cancer Prevention - Argan oil has a unique chemical profile that should have anticancer activity

Cancer Research - NaPro BioTherapeutics licenses peptide targeting technology

Cancer Risk - At-home urine test to evaluate risk for breast cancer

Cancer Therapy - CPT-11 effective against myelodysplastic syndromes with blast excess

Cancer Therapy - Etoposide-loaded red blood cells effective in mice.

Cancer Therapy - Patent grantee for vasopermeation enhancing agents

Cancer Therapy - Progress announced in Medarex Alliance

Cancer Therapy - Scientists alter smallpox vaccine to fight cancer

Cancer Therapy - Suramin analogues reduce the invasive capacity of cancer

Cancer Therapy - Thymosin beta-15 shows strong antiangiogenic potential in laboratory assays

Cancer Therapy - Virulizin results published; FDA grants orphan drug status to GTI-2040

Cancer Vaccine - Mechanisms regulating tumor rejection after vaccination reviewed

Cancer-Associated Kinase - Genomic structure and localization were determined for the human NAK gene

Cell Signaling - Fruit fly cells reveal Hedgehog's secrets

Cervical Cancer - Associated human papillomavirus types vary only somewhat worldwide

Cervical Cancer - FDA approves expanded use of HPV test

Chemotherapy - Vascularity correlates with therapeutic response in liver metastases models

Chemotherapy Complication - Cyclophosphamide urotoxicity may be avoided by coadministering sulphur compounds

Cirrhosis - A new scoring system predicts the risk for liver cancer in hepatitis patients

Colon Cancer - Carcinoembryonic antigen and cytokeratin 20 can warn of peritoneal recurrence

Colon Cancer - ISP induces cell cycle arrest, apoptosis; could be therapeutic lead

Colorectal Cancer - Prior cholecystectomy appears to modestly increase the risk of colorectal cancer

Colorectal Cancer Screening - A computer simulation model can assess cost-effectiveness of cancer screening

DNA Demethylation - Demethylation of the IL-2 gene enhances transcription by an active process

Diagnostics - Telecytology of cervical smears are as effective as slides

Epstein Barr Virus - In chronic active EBV infection, natural killer cells may not express LAIR-1

Esophageal Stricture - Chemoradiotherapy can improve squamous cell carcinoma patient survival

Ewing Sarcoma - Transformation induced by EWS/FLI-I can be suppressed by KRAB/FLI-I

Fanconi Anemia - Telomere metabolism linked to severe aplastic anemia risk

Finance - Company announces closing of $75.3 million round-B financing

Follicular Lymphoma - Gene expression pattern of tumors may predict response to rituximab

Gallbladder Cancer - Etiopathological agents for gallbladder cancer remain unclear

Gastric Cancer - Carcinoembryonic antigen mRNA is a better predictor of recurrence

Gastric Cancer - Effective treatment of H. pylori depends on sensitive and accurate diagnosis

Gastrointestinal Disease - Echoendoscope provides excellent imaging of GI wall and extramural structures

Genetic Counseling - Most gynecologists would offer genetic counseling for breast, ovarian cancer

Glioma - Melanoma differentiation associated gene-7 reduces brain cancer tumorigenicity

Gynecology - Vascular endothelial growth factor-D is a biomarker for ovarian cancer

HIV/AIDS Pathogenesis - Retroviruses use cytoskeletal polarization for cell entry

Head and Neck Cancer - Patients fare worse when missing copy of tumor suppressor gene

Hepatocellular Carcinoma - Transcription factor c-Jun prevents apoptosis by antagonizing p53 activity

Hypereosinophilic Syndrome - Study offers hope for patients with rare blood cancer

Hyperpigmentation - Apomorphine hyperpigmentation can lead to misdiagnosis of metastatic melanoma

Hyperproliferation - High telomerase activity may induce senescent-like growth arrest in fibroblasts

Immunology - New treatment boosts cancer vaccine

Interventional Radiology - Researchers present techniques of percutaneous radiofrequency ablation

Intestinal Diseases - Gastrointestinal stromal tumor found in patient with ulcerative colitis

Intravascular Lymphomatosis - The skin manifestation resulted from chemotherapy of recurrent B-cell lymphoma

Kaposi Sarcoma - KSHV K8 protein interacts with hSNF5

Keratoacanthoma - Topical treatment with imiquimod induces regression or disappearance

Larynx Surgery - Longterm voice outcomes show that transesophageal speech is best option

Leukemia - All-trans-retinoic acid induces CD52 expression in acute promyelocytic leukemia

Leukemia - N-acetyl-leucine amide inhibits cell cycle progression in Jurkat cells

Leukemia Therapy - Alpha-tocopherol reduces cisplatin toxicity

Leukemia Therapy - HA-1- or HA-2-specific T cells can induce complete remission after relapse

Leukemia Therapy - Imatinib exacerbates idarubicin-induced hematopoietic toxicity

Leukemia Therapy - Interleukin-2 with GM-CSF effective in mice