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Cancer Weekly

Susan Hasty, Publisher
Table of Contents . . . April 22nd, 2003
Non-Subscriber - Summaries Only
Related Areas: Other Issues in Cancer Weekly | Other Publications

Cancer Metastasis - Interleukin-1 is a prerequisite for tumor invasion and angiogenesis

Gene Detection - Dual "molecular beacons" might eventually lead to very early cancer diagnosis

Antiangiogenesis - A new hypoxia-dependent agent inhibits tumor-specific neovascularization

Bladder Cancer - Hexvix cystoscopy improves treatment of patients - new phase III results

Body Mass Index - Height, but not weight or BMI, associated increases risk of testicular cancer

Liver Cancer - Researchers probe promising treatment

Sciatic Nerve Tumor - EMG and MRI used to diagnose sciatic nerve tumor in two dogs

Anal Cancer - Shorter irradiation and added mitomycin C are now standard EORTC therapy

Antiangiogenesis - Tissue inhibitor of metalloproteinase-3 limits angiogenesis and neuroblastoma

Anticancer Gene - FHIT induced apoptosis of cancer cells is limited by substrate binding

Antimetastatic Enzyme - Nucleoside diphosphate kinase/NM23 regulates aspects of tumor metastasis

Antioxidant Activity - Liposome assay shows total activity of fruits and vegetables varies tremendously

Antitumor Activity - Agonistic antibodies to CD40 and IL-2 induce dendritic and CD8+ cell activity

Antitumor Agents - Researchers develop potential antitumor agents that inhibit histone deacetylase

Apoptosis - Transcription of PAC1 directly regulated by p53

Appointments - TergeGen names VP of R&D and chief scientific officer

Bladder Cancer - Diagnostics by MRI are comparable with conventional and CT cystoscopy

Bladder Carcinoma - Transitional cell carcinoma presents as a rare case of extensive skin metastases

Bone Metastasis - Severe hypocalcemia can follow a single pamidronate injection

Brain Cancer - Dose components determined for boron neutron capture therapy

Breast Cancer - Analysis of breast cell membranes reveals many undiscovered proteins

Breast Cancer - Core biopsy without image guidance for palpable lumps key due to sensitivity

Breast Cancer - Israeli team uncovers protein responsible for metastases

Breast Cancer - NCI study estimates more than 2 million women could benefit from tamoxifen

Breast Cancer - Studies that are unable to show hair fiber x-ray diffraction changes have flaws

Breast Cancer - The offspring's or father's genotypes may predict mother's breast cancer risk

Breast Cancer - The ortholog of BRCA1 is identified in Arabidopsis thaliana

Breast Cancer - The potency of oral contraceptives influences risk among younger women

Breast Cancer - Variants of XRCC1 and XRCC3 genes may contribute to breast cancer susceptibility

Breast Cancer - iCAD introduces software for use with full field digital mammography systems

Breast Cancer Epidemiology - Marin rates exaggerated by faulty data

CNS Tumors - High ¹²³I-IMP is seen on SPECT image in primary CNS lymphoma

Cancer Gene Therapy - Timing is crucial for HSV-1 thymidine kinase/ganciclovir-mediated cytotoxicity

Cancer Immunology - Specific antitumor antibody patterns exist in sera of patients with lung cancer

Cancer Prevention - Argan oil has a unique chemical profile that should have anticancer activity

Cancer Research - NaPro BioTherapeutics licenses peptide targeting technology

Cancer Risk - At-home urine test to evaluate risk for breast cancer

Cancer Therapy - CPT-11 effective against myelodysplastic syndromes with blast excess

Cancer Therapy - Etoposide-loaded red blood cells effective in mice.

Cancer Therapy - Patent grantee for vasopermeation enhancing agents

Cancer Therapy - Progress announced in Medarex Alliance

Cancer Therapy - Scientists alter smallpox vaccine to fight cancer

Cancer Therapy - Suramin analogues reduce the invasive capacity of cancer

Cancer Therapy - Thymosin beta-15 shows strong antiangiogenic potential in laboratory assays

Cancer Therapy - Virulizin results published; FDA grants orphan drug status to GTI-2040

Cancer Vaccine - Mechanisms regulating tumor rejection after vaccination reviewed

Cancer-Associated Kinase - Genomic structure and localization were determined for the human NAK gene

Carcinogen Testing - Occurrence of aflatoxin M-1 in raw cow's milk appears to be low in Spain

Cell Signaling - Fruit fly cells reveal Hedgehog's secrets

Cervical Cancer - Associated human papillomavirus types vary only somewhat worldwide

Cervical Cancer - FDA approves expanded use of HPV test

Chemotherapy - Vascularity correlates with therapeutic response in liver metastases models

Chemotherapy Complication - Cyclophosphamide urotoxicity may be avoided by coadministering sulphur compounds

Cirrhosis - A new scoring system predicts the risk for liver cancer in hepatitis patients

Colon Cancer - Carcinoembryonic antigen and cytokeratin 20 can warn of peritoneal recurrence

Colon Cancer - ISP induces cell cycle arrest, apoptosis; could be therapeutic lead

Colorectal Cancer - Prior cholecystectomy appears to modestly increase the risk of colorectal cancer

Colorectal Cancer Screening - A computer simulation model can assess cost-effectiveness of cancer screening

DNA Demethylation - Demethylation of the IL-2 gene enhances transcription by an active process

Diagnostics - Telecytology of cervical smears are as effective as slides

Epstein Barr Virus - In chronic active EBV infection, natural killer cells may not express LAIR-1

Esophageal Stricture - Chemoradiotherapy can improve squamous cell carcinoma patient survival

Ewing Sarcoma - Transformation induced by EWS/FLI-I can be suppressed by KRAB/FLI-I

Fanconi Anemia - Telomere metabolism linked to severe aplastic anemia risk

Finance - Company announces closing of $75.3 million round-B financing

Follicular Lymphoma - Gene expression pattern of tumors may predict response to rituximab

Gallbladder Cancer - Etiopathological agents for gallbladder cancer remain unclear

Gastric Cancer - Carcinoembryonic antigen mRNA is a better predictor of recurrence

Gastric Cancer - Effective treatment of H. pylori depends on sensitive and accurate diagnosis

Gastrointestinal Disease - Echoendoscope provides excellent imaging of GI wall and extramural structures

Genetic Counseling - Most gynecologists would offer genetic counseling for breast, ovarian cancer

Glioma - Melanoma differentiation associated gene-7 reduces brain cancer tumorigenicity

Gynecology - Vascular endothelial growth factor-D is a biomarker for ovarian cancer

HIV/AIDS Pathogenesis - Retroviruses use cytoskeletal polarization for cell entry

Head and Neck Cancer - Patients fare worse when missing copy of tumor suppressor gene

Hepatocellular Carcinoma - Transcription factor c-Jun prevents apoptosis by antagonizing p53 activity

Histopathologic Evaluation - Researchers develop tissue list for toxicity, carcinogenicity studies

Hypereosinophilic Syndrome - Study offers hope for patients with rare blood cancer

Hyperpigmentation - Apomorphine hyperpigmentation can lead to misdiagnosis of metastatic melanoma

Hyperproliferation - High telomerase activity may induce senescent-like growth arrest in fibroblasts

Immunology - New treatment boosts cancer vaccine

Infrared Spectroscopy - Cells in suspension reduces measurement artifact, more accurate than dried cells

Interventional Radiology - Researchers present techniques of percutaneous radiofrequency ablation

Intestinal Diseases - Gastrointestinal stromal tumor found in patient with ulcerative colitis

Intravascular Lymphomatosis - The skin manifestation resulted from chemotherapy of recurrent B-cell lymphoma

Kaposi Sarcoma - KSHV K8 protein interacts with hSNF5

Keratoacanthoma - Topical treatment with imiquimod induces regression or disappearance

Larynx Surgery - Longterm voice outcomes show that transesophageal speech is best option

Leukemia - All-trans-retinoic acid induces CD52 expression in acute promyelocytic leukemia

Leukemia - N-acetyl-leucine amide inhibits cell cycle progression in Jurkat cells

Leukemia Therapy - Alpha-tocopherol reduces cisplatin toxicity

Leukemia Therapy - HA-1- or HA-2-specific T cells can induce complete remission after relapse

Leukemia Therapy - Imatinib exacerbates idarubicin-induced hematopoietic toxicity

Leukemia Therapy - Interleukin-2 with GM-CSF effective in mice

Leukemia Therapy - ST1571 pretreatment improves donor lymphocyte infusion efficacy

Leukemia Therapy - Timed sequential therapy with ATRA effective in adult patients

Liposarcoma - Overdiagnoses can occur due to presence of non-lipomatous areas in lipomas

Liver Cancer - Angiostatin gene therapy arrests the growth of hepatocellular carcinoma

Liver Cancer - Gene content analysis defines minimum LOH region in HCC on chromosome 17p13.3

Liver Cancer - Hepatitis B virus DNA may hasten hepatitis C-related liver cancer formation

Liver Cancer - The cyclin A promoter encourages effective gene delivery to hepatoma cells

Lung Cancer - Bronchial preinvasive lesion prevalence is high in specific risk groups

Lung Cancer - Cisplatin and etoposide therapy can be used even in hemodialysis patients

Lung Cancer - Combined chemotherapy and radiotherapy for inoperable NSCLC may be promising

Lung Cancer - Combined topotecan and gemcitabine can be used on advanced disease

Lung Cancer - Combining local and systemic treatment may lead to improved long-term survival

Lung Cancer - Difference mortality between sexes may be due to equalization of work roles

Lung Cancer - PET scanning improves the selection of patients for combined modality treatment

Lung Cancer - Serum anti-p53 autoantibodies may be associated with survival in some cases

Lung Cancer - Serum microparticles from monocytes, platelets may signal vascular complication

Lung Cancer Therapy - Irinotecan/cisplatin gets partial response in advanced non-small cell cancer

Lymphoma - Endothelial stimulation in lymphoma parallels growth factor secretion

Lymphoma - Proliferation gene expression may have prognostic value

Lymphoma Therapy - Stem cell autografts effective against mantle cell lymphoma in remission

Mammography - Counseling for psychological consequences of screening mammography is beneficial

Melanoma - Increased tumor blood perfusion advances the uptake of therapeutic agents

Melanoma - Resveratrol is potent inducer of apoptosis, may be therapeutic agent

Melanoma - Tumor-activated hepatic stellate cells generate proangiogenic microenvironments

Metastasis - KISS1 gene is involved in metastasis suppression and many other cell functions

Metastasis Suppression - Novel human NM23-H1B gene distinguishes colon cancers from normal

Metastasis Suppression - nm23 Metastasis suppression may involve diminished signal transduction

Metastatic Carcinoma - Aggressive ameloblastic carcinoma is fatal 4 years after diagnosis

Metastatic Disease - Metastasis may be regulated by stress pathways; expression may confer advantage

Metastatic Suppression - MKK4 plays a role in the suppression of metastasis; may have therapeutic use

Multiple Myeloma - First-line chemotherapy improves survival in responding and stable patient sets

Multiple Myeloma - Thalidomide may delay progression of early-stage disease

Muscular Apoptosis - Caspase proteolysis of desmin produces an inhibitor of filament assembly

Neuroblastoma Cell Lines - Parc is critical regulator in controlling p53 subcellular localization, function

Non-Melanoma Skin Cancer - Mitochondrial DNA damage that is heteroplastic is found tumor specific

Nutrition - It takes two to fight cancer

Oncogenesis - The angiogenic phenotype of Kaposi sarcoma is regulated by an oncogene

Oncology - Adenovirus shedding is detected after gene transfer into lung cancer tumors

Oncology - Intense vessel growth is a hallmark of inflammatory breast cancer

Oncology - Thrombospondin 1 regulates adenoma growth and carcinoma progression

Ophthalmology - Researchers discover mechanism used to prevent abnormal blood vessel growth

Osteosarcoma - S1P, LPA incubation induced proliferation which lessens in Gi inhibitor presence

Ovarian Cancer - Cyst fluid biomarkers can reveal important information about ovarian tumors

Ovarian Cancer - Phase III registration trial of TLK286 begins

Pancreatic Cancer - Adrenomedullin antagonists suppress pancreatic tumors by blocking angiogenesis

Pancreatic Cancer - Data presented on lead product candidate TNFerade

Pancreatic Cancer - Perioperative hyperlactatemia is correlated to adverse outcome

Pancreatic Cancer - Virulizin shows activity against tumors in mouse model

Papillary Thyroid Cancer - Dipeptidyl peptidase IV expression effective in diagnosing thyroid cancer

Papillomavirus Testing - The sexually transmitted aspect of disease may create psychosocial problems

Patents - Therapeutic composition patent granted for Product R

Pediatric Cancer - Study shows that children with cancer view their lives as routine and ordinary

Primary Renal Lymphoma - Lymphoid-tissue type lymphomas are a distinct form of B-cell malignant lymphoma

Prostate Cancer - Abundance ratio-dependent proteomic analysis is performed with mass spectrometry

Prostate Cancer - An androgen receptor mutant, AR(M749L), has hypersensitivity to estrogens

Prostate Cancer - Androgen blockade and early screening have increased survival

Prostate Cancer - Antiandrogen monotherapy with bicalutamide is the most effective therapy

Prostate Cancer - Antiandrogens can be selective androgen receptor modulators, tools in therapy

Prostate Cancer - DOC-2/DAB2 can modulate c-Src in prostatic epithelium and cancer

Prostate Cancer - Evidence suggests that chromosome 19 harbors a gene for tumor aggressiveness

Prostate Cancer - Nonviral transfer of the Fas ligand gene suppresses prostate tumors

Prostate Cancer - Prostate adenocarcinoma rarely presents with inguinal lymphadenopathy

Prostate Cancer - Prostate cancer can metastasize to the radial head causing wrist drop

Prostatic Carcinosarcoma - Researchers report a case of carcinosarcoma with two histologic elements

Proteomics - ECTO-NOX proteins in sera have characteristics similar to those of cell surface

Proteomics - Zn2+ loss may represent a significant inactivation pathway for p53 in the cell

Pulmonary Medicine - Cadherin overexpression is critical for the lung metastasis of osteosarcoma

Radiation Exposure - Thyroid complications aren't present in nuclear test site neighbors' children

Radiosensitivity - Model may benefit patient selection when cultures fail to determine sensitivity

Rectal Cancer - EM useful technique to differentiate Paget's disease, pagetoid phenomenon

Renal Cancer - Ring-enhanced malignant meningioma mimicked a brain metastasis

Renal Carcinoma - Dialysis patient develops rare chromophobe cell renal carcinoma

Skeletal Sarcoidosis - Sarcoidosis mimics metastatic disease on PET scan and bone scintigraphy

Skin Cancer - Parental Sun Protection Scales can help determine practices, improve behavior

Skin Cancer - Polymorphisms in RAD30 might add to risk; screening methods have been developed

Squamous Cancer - Lack of differentiation may be caused by beta 1 integrin mutation

Stem Cell Research - Mixed lineage leukemia oncoprotein transforms multipotent hematopoietic progenitors

Steroid Therapy Risk - Methylprednisolone treatment induced tumor lysis syndrome and renal failure

Thrombophlebitis - Spontaneous thrombophlebitis may be associated with distant malignancies

Thyroid Cancer - Risk in females may be related to hormonal/reproductive factors

Tumor Development - Consumption of pulses may help to reduce risk of tumor development

Tumor Growth - Fagopyrum cymosum inhibits in vitro tumor growth of some cancer cells

Tumor Suppression - Shark enzyme inhibitor interferes with capillary construction and tumor growth

Tumorigenesis - Int6, either alone or with Ras, influences proteasome activities via Rpn5

Ureteral Cancer - Complete remission of ureteral cancer results from taxan containing chemotherapy

Vector Development - Baculovirus is an effective vector for transfecting osteogenic sarcoma cells

Vector Development - Live bacteria as tumor-selective protein delivery vectors in clinical trials

Vestibular Schwannoma - Postsurgical facial nerve function depends on edema and brainstem response

Virology - Enzyme polymorphisms increase hepatic susceptibility in hepatitis C

Virology - Some adenoviruses have a greater affinity for cancer and endothelial cells

Xeroderma Pigmentosum - Skin diseases reveal information useful to skin tumor research

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