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Anticancer Gene
FHIT induced apoptosis of cancer cells is limited by substrate binding
April 22nd, 2003
Fhit-induced apoptosis of cancer cells is limited by substrate binding. According to a study from the United States, "The FHIT gene is inactivated early in the development of many human tumors, and Fhit-deficient mice have increased cancer incidence. Viral reexpression of Fhit kills Fhit-deficient cells by induction of apoptosis. "Fhit, a member of branch 2 of the histidine-triad superfamily of nucleoside monophosphate hydrolases and transferases, is a diadenosine polyphosphate hydrolase, the active-site histidine of which is not required for tumor suppression. "To provide a rigorous test of the hypothesis that Fhit function...
Source: Cancer Weekly (2003-04-22)
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