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Antimetastatic Enzyme
Nucleoside diphosphate kinase/NM23 regulates aspects of tumor metastasis
April 22nd, 2003
Tumor metastasis appears to be controlled by a housekeeping enzyme involved in altering cancer cell growth, differentiation, and motility. "Nucleoside diphosphate kinase (NDPK/nm23) is a ubiquitously distributed housekeeping enzyme involved in the high energy transfer to produce nucleoside triphosphates pools at the expense of ATP. It causes metastasis suppression of a number of cultured tumor cell lines of various origins. We have investigated the mechanism by which NDPK/nm23 suppresses metastasis using a rat mammary adenocarcinoma cell line, MTLn3, and a human squamous cell carcinoma cell line, LMF4," researchers in Japan report. "The...
Source: Cancer Weekly (2003-04-22)
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