Pancreatic Cancer
Adrenomedullin antagonists suppress pancreatic tumors by blocking angiogenesis
Published in Cancer Weekly, April 22nd, 2003
"Since it is reported that adrenomedullin (AM) upregulated by hypoxia inhibits hypoxic cell death, we examined the effects of AM antagonist (AM C-terminal fragment; AM(22-52)) on the growth of pancreatic cancer cells. We, for the first time, demonstrated that AM antagonist significantly reduced the in vivo growth of the pancreatic cancer cell line," according to researchers in Japan.
"Immunohistochemical analysis demonstrated that the mean diameter of blood vessels was significantly smaller in the tumor tissues treated with AM antagonist than in those treated with AM...
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Source: Cancer Weekly (2003-04-22)
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