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Apoptosis
Transcription of PAC1 directly regulated by p53
April 22nd, 2003
Some damaged cells can be fixed, but others have to die. It has been a puzzle how the tumor suppressor p53 determines the cell's fate depending on the damage done. Nature reports that the phosphatase PAC1 is necessary and sufficient to induce p53-dependent cell death. The tumor suppressor p53 coordinates various cellular processes by regulating the transcription of specific genes. Yuxin Yin of the College of Physicians and Surgeons, Columbia University, New York City now show that the transcription of PAC1 - known to inactivate the MAP kinase cell-survival pathway - is directly regulated by p53. PAC1 is activated only by...
Source: Cancer Weekly (2003-04-22)
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