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Bone Metastasis
Severe hypocalcemia can follow a single pamidronate injection
April 22nd, 2003
Severe hypocalcemia can follow a single pamidronate injection for treatment of patients with bone metastasis and no initial hypercalcemia. "Bisphosphonates such as pamidronate are a new class of drugs initially described for treatment of neoplasic hypercalcemia. Currently, they also may be used in the treatment of bone metastases from solid tumor, even without hypercalcemia. Hypocalcemia is a potential adverse effect of these drugs, which is considered infrequent and rarely symptomatic," researchers in France report. "We describe 3 cases of severe hypocalcemia following one injection of pamidronate. The 3 patients had bone metastases from solid...
Source: Cancer Weekly (2003-04-22)
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