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Cancer Metastasis
Interleukin-1 is a prerequisite for tumor invasion and angiogenesis
April 22nd, 2003
Interleukin-1 is a prerequisite for tumor invasion and angiogenesis. "Here, we describe that microenvironmental interleukin (IL)-1beta and, to a lesser extent, IL-1alpha are required for in vivo angiogenesis and invasiveness of different tumor cells," scientists writing in the journal Proceedings of the National Academy of Sciences USA report. "In IL-1beta knockout (KO) mice, local tumor or lung metastases of B16 melanoma cells were not observed compared with wild-type (WT) mice. Angiogenesis was assessed by the recruitment of blood vessel networks into Matrigel plugs containing B16 melanoma cells; vascularization of the plugs was present in...
Source: Cancer Weekly (2003-04-22)
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