Cancer Weekly
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Breast Cancer
Analysis of breast cell membranes reveals many undiscovered proteins
April 22nd, 2003
Over 500 breast cancer specific proteins were identified in a comprehensive analysis of breast cancer cell membranes. "Proteins associated with cancer cell plasma membranes are rich in known drug and antibody targets as well as other proteins known to play key roles in the abnormal signal transduction processes required for carcinogenesis. "We describe here a proteomics process that comprehensively annotates the protein content of breast tumor cell membranes and defines the clinical relevance of such proteins. Tumor derived cell lines were used to ensure an enrichment for cancer cell-specific plasma membrane proteins because it is difficult to...
Source: Cancer Weekly (2003-04-22)
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