Cancer Weekly
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Breast Cancer
Israeli team uncovers protein responsible for metastases
April 22nd, 2003
Israeli biologists have demonstrated that a specific protein induces breast cancer cells to invade other tissues and acquire properties that are characteristic of metastatic tumor cells. When tumors metastasize, they can no longer be cured by surgery alone and generally kill the patient rapidly. The protein, called lysyl-oxidase-related protein 1 (LOR-1), both causes tumors to spread and induces the deposition of large amounts of collagen fibers that are a hallmark of deadly breast cancers. The team believes that chemicals that block or inhibit LOR-1 may be developed as possible treatments for breast cancer, preventing metastasis. The team was led...
Source: Cancer Weekly (2003-04-22)
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