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Breast Cancer
The ortholog of BRCA1 is identified in Arabidopsis thaliana
April 22nd, 2003
The ortholog of BRCA1 is identified in Arabidopsis thaliana. According to recent research from France, "hBRCA1 is involved in 20% - 45% of inherited breast cancer cases and is implicated in many mechanisms involved in response to DNA damage. To date, BRCA1 orthologs have been characterized in vertebrate genomes only. "We have identified the ortholog of BRCA1 in Arabidopsis thaliana. AtBRCA1 is a 5.5 kb part of the locus At4g21070. The corresponding mRNA of 3.5 kb is composed of 14 exons and encodes a 941 amino acid protein (104 kDa). AtBRCA1, which has one N-terminal RING finger, two C-terminal BRCT and the p300/CBP interacting domain, shows a...
Source: Cancer Weekly (2003-04-22)
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