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Breast Cancer

Variants of XRCC1 and XRCC3 genes may contribute to breast cancer susceptibility

"Mammalian cells are constantly exposed to a wide variety of genotoxic agents from both endogenous and exogenous sources. Genetic variability in DNA repair may contribute to human cancer risk," researchers in the United States report.

"We used a case-control study design (162 cases and 302 controls) to test the association between three amino acid substitution variants of DNA repair genes (XRCC1 Arg194Trp, XRCC1 Arg399Gln, and XRCC3 Thr241Met) and breast cancer susceptibility," wrote T.R. Smith and colleagues, Wake Forest University, School of Medicine.

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