Cancer Weekly
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Cancer-Associated Kinase
Genomic structure and localization were determined for the human NAK gene
April 22nd, 2003
A new kinase gene, NAK, was studied and mapped to a chromosome region where LOH is associated with squamous cell carcinoma and leukemia. According to recent research from Japan, "NAK has been identified as an IkappaB-kinase activating-kinase that plays an important role in NF-kappaB activation in response to several pro-inflammatory cytokines such as TNF-alpha. We describe here the genomic structure of the human NAK gene and analysis of the promoter. "The gene spanned 40.5 kb and contained 21 exons with lengths ranging from 39 to 196 bp. Comparison of the phase and position of intron insertions within the human NAK gene with those within IKKalpha,...
Source: Cancer Weekly (2003-04-22)
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