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Cell Signaling
Fruit fly cells reveal Hedgehog's secrets
April 22nd, 2003
A Johns Hopkins-led research team has successfully used a technique to rapidly find fruit fly genes involved in a cell signaling pathway called Hedgehog, which is critical to proper embryo development and a key trigger in some cancers, including the deadly childhood brain cancer medulloblastoma. By using the technique, called RNA interference, to "knock down" the messages of specific genes in fruit fly cells, researchers from Johns Hopkins and the U.S. National Institutes of Health screened 43% of the fruit fly's genes and found four new players involved in passing along Hedgehog's signal. Reporting in Science, the scientists also suggested...
Source: Cancer Weekly (2003-04-22)
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