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Chemotherapy Complication
Cyclophosphamide urotoxicity may be avoided by coadministering sulphur compounds
April 22nd, 2003
By coadministering diallyl sulfide compounds with cyclophosphamide, necrotic type pathology in the bladder was avoided in mice. According to a study from India, "Treatment of Swiss albino mice with naturally occurring sulphur compounds such as Diallyl sulphide (DAS) (500 mug/dose/animal, i.p) and Diallyl Disulphide (DADS)(250 mug/dose/animal, i.p) for five days along with cyclophosphamide (CTX) (1.5 mmol/kg.body.wt; i.p) reduced the CTX induced urotoxicity. "Morphological analysis of the urinary bladders of the CTX treated group showed severe inflammation and dark colouration whereas the sulphur compounds treated group showed almost normal bladder...
Source: Cancer Weekly (2003-04-22)
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