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Colon Cancer
ISP induces cell cycle arrest, apoptosis; could be therapeutic lead
April 22nd, 2003
Isostrychnopentamine (ISP) induces cell cycle arrest and apoptosis in colon cancer; it could be therapeutic lead. According to a study from Belgium, "Isostrychnopentamine (ISP) is an indolomonoterpenic alkaloid that is present in the leaves of Strychnos usambarensis, a well known African shrub or little tree. "The roots contain quaternary alkaloids, which are used to make a curare-like arrow poison. However, tertiary alkaloids isolated from the same plant possess cytotoxic activities against mammalian cells and protozoa," stated M. Frederich and coauthors, University of Liege, Natural & Synthetic Drug Research Center. "The...
Source: Cancer Weekly (2003-04-22)
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