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DNA Demethylation
Demethylation of the IL-2 gene enhances transcription by an active process
April 22nd, 2003
Demethylation of the IL-2 gene enhances transcription by an active process. According to a study from the United States, "A role for DNA demethylation in transcriptional regulation of genes expressed in differentiated somatic cells remains controversial. "Here, we define a small region in the promoter-enhancer of the interleukin-2 (II2) gene that demethylates in T lymphocytes following activation, and remains demethylated thereafter. This epigenetic change was necessary and sufficient to enhance transcription in reporter plasmids," stated D. Bruniquel and coauthors, NIAID, Cellular & Molecular Immunology Laboratory. Bruniquel and...
Source: Cancer Weekly (2003-04-22)
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