Cancer Weekly
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Epstein Barr Virus
In chronic active EBV infection, natural killer cells may not express LAIR-1
April 22nd, 2003
Chronic active Epstein-Barr virus infection (CAEBV) produces natural killer cells with little or no expression of the typical leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1). According to recent research from Canada, "CAEBV infection is an uncommon and severe manifestation of EBV infection that frequently leads to the development of natural killer (NK) or T cell lymphomas. "NK cells derived from a boy with CAEBV showed decreased cytotoxic function and impaired interferon-gamma secretion against a variety of transformed target cell lines. In addition, NK cells from the patient lacked expression of the broadly expressed NK receptor,...
Source: Cancer Weekly (2003-04-22)
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