Ewing Sarcoma

Transformation induced by EWS/FLI-I can be suppressed by KRAB/FLI-I

Published in Cancer Weekly, April 22nd, 2003

The chimeric transcription factor EWS/FLI-I of Ewing sarcoma can be suppressed by KRAB/FLI-I, leading to reversal of transformed phenotype.

According to a study from Australia, "Ewing sarcoma is a childhood bone tumor with poor prognosis, most commonly associated with a t(11;22)(q24;q12) reciprocal translocation that fuses the EWS and FLI-1 genes, resulting in the production of an aberrant chimeric transcription factor EWS/FLI-1.

"To elucidate the mechanisms by which EWS/FLI-1 mediates transformation in mouse models, we have generated a murine Ews/Fli-1 fusion protein. We demonstrate that this protein transforms fibroblast cells in vitro similar to...

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Source: Cancer Weekly (2003-04-22)

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