B Cell Malignancies

Profiling B cell transcriptional germinal center aids malignancy studies

Published in Cancer Weekly, April 29th, 2003

The normal sequence of gene transcription from naive to memory B cells is complex and disrupted in B cell malignancy.

According to a study from the United States, "The germinal center (GC) reaction is crucial for T cell-dependent immune responses and is targeted by B cell lymphomagenesis. Here we analyzed the transcriptional changes that occur in B cells during GC transit (naive B cells --> centroblasts --> centrocytes --> memory B cells) by gene expression profiling.

"Naive B cells, characterized by the expression of cell cycle-inhibitory and antiapoptotic genes, become centroblasts by inducing an atypical proliferation program lacking...

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Source: Cancer Weekly (2003-04-29)

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