Hepatocellular Carcinoma

Molecular relationship between multiple tumor nodules studied

Published in Cancer Weekly, April 29th, 2003

University of Hong Kong pathologists studied "the molecular relationship between multiple tumor nodules in hepatocellular carcinoma (HCC) within individual patients and [evaluated] their clonality, which may bear prognostic significance."

"In 25 HCC nodules from 11 patients with multiple HCCs, the clonal relationships of the nodules within individual patients were determined using DNA fingerprinting with loss of heterozygosity (LOH) assay, comparative genomic hybridization (CGH), and hepatitis B virus (HBV) integration pattern," according to a report by I.O.L. Ng and colleagues.

They reported that multiple HCCs in four patients (11%) "had different...

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Source: Cancer Weekly (2003-04-29)

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