Cancer Weekly

Prostate Cancer - Sequence matters when using novel agent

Thyroid Cancer - Common thyroid cancer gene mutation found

B Cell Lymphoma - The P54-cleaved tyrosine kinase Lyn stops B cell receptor induced apoptosis

DNA Vaccine - Transdermal gene delivery eradicates tumors expressing hepatitis C proteins

Head and Neck Cancer - COX-2 correlates with cancer mechanisms in esophageal squamous cell carcinoma

Ovarian Cancer - The wine derivative resveratrol alters genetic expression in cancer cells

ATM Mutations - Some ATM carriers are predisposed to cancer

Acute Lymphoblastic Leukemia - Standardized serum-free culture for tumor cells developed

Acute Myeloid Leukemia - Compound triggers release of nitric oxide to fight leukemia and tumors

Acute Myeloid Leukemia - Genetic risk factors identified in mice

Acute Myeloid Leukemia - t(10;16)(Q22;p13) and MORF-CREBBP fusion is a recurrent event in AML

Adoptive Immunotherapy - Roadblocks to tumor vaccines could be overcome with interleukin-2

Antiangiogenesis - A new assay can be used for evaluating substances that halt angiogenesis

Anticancer Drugs - Anticancer drug mithramycin is associated with H1-depleted chromatin

Antitumor Activity - A novel atypical retinoid is endowed with proapoptotic and antitumor activity

Antitumor Drugs - A disaccharide anthracycline, MEN 10755, can binds 2 DNA helices simultaneously

Apoptosis - Spike, a novel BH3-only protein, mediates proapoptotic signals

Apoptosis Suppressor - TERT requires reverse transcriptase activity and 14-3-3 protein binding ability

Atherosclerosis - Epigallocatechin-3 gallate can activate p53 and induce apoptosis

B Cell Lymphomas - MUC-1 mucin protein expression is common in any state of disease

B Cell Regulation - Pten in B cells controls homeostasis and IgG class switch recombination

Barrett Esophagus - Metaplasia and carcinogenesis may result from increased metallothionein

Basal Cell Carcinoma - The molecular pathogenesis of BCC differs markedly from most other cancers

Biostatistics - A comparison of drug therapies based on toxicity and efficacy has been developed

Bladder Cancer - 8q24 amplification occurs in transitional cell carcinoma of bladder

Bone Cancer - Adamantinoma was found with discrete osteofibrous dysplasia in an ulna

Bone Marrow Transplant - Donor T cell-derived TNF is required for graft-versus-host disease

Brain Tumors - Patients receiving a Gliadel wafer have a higher incidence of infection

Breast Cancer - An antisense gene targeting strategy could make breast tumors chemosensitive

Breast Cancer - Bidirectional signaling between EGFR and ER contributes to pathophysiology

Breast Cancer - Caelyx - a novel agent in the fight against metastatic breast cancer

Breast Cancer - Data support an important role for TP53 in mammary carcinogenesis

Breast Cancer - Decision tool benefits women considering adjuvant chemotherapy

Breast Cancer - Discovery of how prolactin travels to gene's machinery helps explain role

Breast Cancer - In breast cancers, 24 genes showed significant overexpression

Breast Cancer - Isoliquiritigenin in licorice has estrogenic and antiproliferative activities

Breast Cancer - Organized mammography screening does not result in overdiagnosis of cancer

Breast Cancer - Percutaneous 4OHTam may be a useful alternative to tamoxifen

Breast Cancer - Peroxisome receptor gamma agonists reduce estrogen receptor alpha

Breast Cancer - Rare metaplastic breast malignancies often reveal extensive vascularity

Breast Cancer - TP53 mutations may occur in familial breast cancer

Breast Cancer - There is tight correlation between the expression of HGF, matriptase, and MET

Breast Cancer - Tumor cells in blood may indicate more aggressive cancer

Breast Cancer - Tumor suppressors p16INK4a and p14ARF are linked and not inactivated by mutation

Breast Cancer - Two biomarkers are valuable for predicting women's response to tamoxifen

Breast Cancer Screening - Levels of pain associated with mammography low

Breast Cancer Vaccine - Vaccine elicits tumor-specific antibodies in patients with breast cancer

Cancer Cell Apoptosis - The prodomain of IL-1 alpha interacts with RNA processing elements

Cancer Cell Lines - 4-Hydroxymethyl-3-aminoacridine derivatives are new anticancer agents

Cancer Genetics - Understanding cancer requires new statistical and computational approaches

Cancer Histochemistry - Hue-Saturation-Intensity (HSI) works better than the gold standard

Cancer Immunotherapy - Noncovalent scFv multimers of tumor-targeting humanized antibody constructed

Cancer Metastasis - Interleukin-8 may potentially be responsible for invasive pancreatic cancer

Cancer Pain - Better directions and practice screens would improve PAINReportIt questionnaire

Cancer Research - Researchers demonstrate broad use of Ciphergen's SELDI ProteinChip Technology

Cancer Susceptibility - Mammalian Exo1 functions in mutation avoidance

Cancer Therapy - Agents resembling 2-methoxyestradiol may be able to combat tumor growth

Cancer Therapy - Angiogenesis targeting is one way that immunotherapy could fight cancer

Cancer Therapy - Company provides update on pipeline of marine compounds

Cancer Therapy - Data on TLK286 and TLK199 reported

Cancer Therapy - Lung cancer study combines gene expression and protein expression

Cancer Therapy - New findings published on diagnostic applications of HAAH Oncology Program

Cancer Therapy - Novel dihydroartemisinin ethers cytotoxic to tumor cells

Cancer Therapy - Programmable antibodies described by scientists

Cancer Therapy - Study offers new insights into angiogenesis inhibitors

Cancer Vaccine - CD4+ cells play critical role in tumor immunity against simian virus 40 antigen

Cancer Vaccine - CTLA-4 blockade enhances effect of poxvirus vaccine targeting p53 in tumor model

Cancer Vaccine - Tumor therapy with epidermal growth factor receptor vaccine investigated

Carcinogenesis - DOCK4, a GTPase activator, is disrupted during tumorigenesis

Carcinoma - Some mucinous colon cancers have less angiogenic phenotypes

Cell Metabolism - ELF-electromagnetic fields induce apoptosis

Cellular Migration - P27(Kip1)/cyclin-dependent kinase/retinoblastoma pathway is regulatory

Cervical Cancer - Mutation of p53 appears to be unrelated to the presence or absence of HPV

Cervical Cancer - New approaches to cervical screening may lead to clinical benefit

Chemotherapy - Antiangiogenic drugs improve survival of metastatic colon cancer in mice

Chemotherapy - Tetrathiomolybdate prevents bleomycin-induced pulmonary fibrosis

Chemotherapy Fatigue - Supplement reduced chemotherapy induced fatigue

Chemotherapy Risk - Therapy-related myelodysplastic syndrome can occur by rearrangement of MOZ gene

Chronic Myeloid Leukemia - Post-transplant blast crisis can mimic de novo lymphoma

Colon Cancer - Heat shock prevents release of apoptosis-inducing factor and caspases in cells

Colon Cancer - Intestinal lymphomas should be diagnosed following universal standards

Colon Cancer - Red meat doneness and panfrying are associated most with risk

Colon Cancer - Study questions interval for screening sigmoidoscopy

Colorectal Cancer - Colorectal cancer prognosis has improved

Colorectal Cancer - Inhibitors of P-glycoprotein may be chemopreventive agents

Colorectal Cancer - Nuclear export of the APC tumor suppressor controls beta-catenin function

Colorectal Cancer - Patterning is a relevant concept for tumor formation

Colorectal Cancer - SLIT2 is an excellent candidate tumor suppressor gene for colorectal cancer

Colorectal Cancer - TP53 mutation status may make a difference in chemotherapeutic outcome

DNA Methylation - Human cancer cell lines have tissue type specific patterns

DNA Transcription - AP-2 alpha's DNA binding is enhanced by the oncogene DEK

Dendritic Cells - Efficient gene transfer into dendritic cells accomplished by electroporation

Dermatology - Protein kinase signals underlie melanocyte transformation to melanoma

Endometrial Adenocarcinoma - Biosynthesis of MUC1 mucin is modulated by estradiol and tamoxifen

Endometrial Cancer Risk Factor - Obesity contributes to estrogen-dependent diseases of female genital organs

Enzymology - Tumor markers could guide therapeutic strategies for invasive breast cancer

Epidemiology - A score test can determine non-inferiority with respect to long-term survival

Epithelial Carcinoma - Inhibition of the PI3K-Akt/PKB survival pathway may contribute to apoptosis

Eukaryotic Cell Cycle - p53, BLM functionally interact during resolution of stalled DNA replication

Gastrointestinal Cancer - Genetic inactivation of ACVR2 gene may indicate it is a tumor suppressor

Gene Mapping - Complete activity of genes documented for both healthy and cancerous cells

Gene Mutations - Caution required when analyzing the significance of p53 mutations

Glioblastoma - Temozolomide can induce apoptosis, but resistance occurs if given in low doses

Healthcare Access - Uninsured cancer patients pay more, get less care

Hematology - Distinctive vascular patterns emerge in non-Hodgkin lymphoma

Hepatocarcinogenesis - E2F1 blocks and c-Myc accelerates hepatic ploidy in transgenic mouse models