Published in Cancer Weekly, May 6th, 2003
According to a study from Germany, "Myeloma bone disease is due to interactions of myeloma cells with the bone marrow microenvironment, and is associated with pathologic fractures, neurologic symptoms and hypercalcemia.
"Adjacent to myeloma cells, the formation and activation of osteoclasts is increased, which results in enhanced bone resorption. The recent characterization of the essential cytokine of osteoclast cell biology, receptor activator of NF-kappaB ligand (RANKL) and its antagonist osteoprotegerin (OPG), have led to a detailed molecular and cellular...
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