Radiation Damage

No chromosomal instability was found in radiation exposed normal fibroblasts

Published in Cancer Weekly, May 6th, 2003

No chromosomal instability in descendants was found in normal fibroblasts exposed to low or high LET radiation.

"Radiation induced genomic instability has been proposed as a very early, if not an initiating step in radiation carcinogenesis. Numerous studies have established the occurrence of radiation induced chromosomal instability in various cells of both human and rodent origin.

"In many of these studies, however, the cells were not normal initially; in many cases they involved tumor derived cell lines," scientists in the United States report.

"The phenomenon clearly would be of even greater interest if it were shown to occur...

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Source: Cancer Weekly (2003-05-06)

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