Basal Cell Carcinoma

The molecular pathogenesis of BCC differs markedly from most other cancers

Published in Cancer Weekly, May 6th, 2003

The molecular pathogenesis of basal cell carcinomas (BCC) differs markedly from most other cancers.

"Abnormal hedgehog signaling, most commonly caused by loss of PTCH1 inhibitor activity, drives tumorigenesis of basal cell carcinomas (BCCs)," scientists writing in the journal Cancer Research report.

"To assess whether other tumors also have abnormal hedgehog signaling, we have assayed RNA from common cancers at nine different sites for levels of expression of hedgehog target genes that are up-regulated uniformly in BCCs," wrote Z.L. Hu and colleagues, San Francisco General Hospital, Department of Dermatology.

The...

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Source: Cancer Weekly (2003-05-06)

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