Cancer Vaccine

CTLA-4 blockade enhances effect of poxvirus vaccine targeting p53 in tumor model

Published in Cancer Weekly, May 6th, 2003

A CTLA-4 blockade enhanced the therapeutic effect of an attenuated poxvirus vaccine targeting p53 in an established murine tumor model.

"p53 is overexpressed by half of all cancers, and is an attractive target for a vaccine approach to immunotherapy. p53 overexpression is frequently the result of point mutations, which leaves the majority of the protein in its wild-type form. Therefore, the majority of p53 sequence is wild type, making it a self-protein for which tolerance plays a role in limiting immune responses," scientists in the United States report.

"To overcome tolerance to p53, we have expressed wild-type murine p53 in the nonpathogenic...

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Source: Cancer Weekly (2003-05-06)

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