Published in Cancer Weekly, May 6th, 2003
"p53 is overexpressed by half of all cancers, and is an attractive target for a vaccine approach to immunotherapy. p53 overexpression is frequently the result of point mutations, which leaves the majority of the protein in its wild-type form. Therefore, the majority of p53 sequence is wild type, making it a self-protein for which tolerance plays a role in limiting immune responses," scientists in the United States report.
"To overcome tolerance to p53, we have expressed wild-type murine p53 in the nonpathogenic...
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