Cancer Weekly

Breast Cancer - Gene expressed in 80% of patients

Ovarian Cancer - Study suggests cells can alter surroundings to promote chemotherapy resistance

Brain Cancer - Radiotherapy and heparin enhance the antiangiogenic effects of SU5416

Cancer Therapy - The mechanics of antitumor activity outlined

Cell Biology - Firefly light helps destroy cancer cells

Pain Medicine - Rapid increase of opioids benefits some dying pediatric cancer patients

Acute Myeloid Leukemia - Human leukocyte antigens, co-stimulatory molecules have varied expression

Acute Myeloid Leukemia - Translocation t(9;11) appears to be related to a damage-repair mechanism

Acute Myeloid Leukemia - p15 methylation was an early event in the evolution of some AML patients

Adenovirus Transformation - Chromatin repression by histone deacetylation downregulates MHC-I transcription

Adrenocortical Carcinoma - Ruptured adrenocortical carcinoma causes pediatric acute abdomen

Advanced Directives - Patients have the right to document their treatment/nontreatment preferences

Aggressive Cancers - Nasal-type NK/T cell lymphoma of the orbit can occur

Anticancer Therapy - Cisplatin induces reticulum stress and nucleus-independent apoptotic signaling

Antitumor Activity - 2-(4-aminophenyl)benzothiazoles create DNA adducts in human tumor cells

Antitumor Immunity - Sigma receptor agonists upregulate IL-10 and increase lung tumor growth

Autologous Transplantation - Purging with MC540-PDT and Edelfosine eliminates more live tumor cells

Autolytic Protein Activation - Membrane type-1 matrix metalloproteinase acts to self-cleave into multiple forms

Benzene Toxicity Model - Susceptibility may be due to NADPH:Quinone oxidoreductase-1 gene and sex

Bioengineering - Macromolecular carriers play an integral role in modulating cancer activity

Bladder Adenocarcinoma - Metastasis to the ovaries is rare but possible

Bladder Cancer - Workers exposed to beta-napthylamine are screened annually

Bladder Tumor Cells - Neurotrophin receptor p75 acts as a tumor suppressor, inhibiting proliferation

Bone Tumors - Highly malignant osteosarcoma is juxtaposed to areas of benign giant cell tumor

Brain Cancer Biopsy - Diagnosis of cerebral ischemia in less than 1% of patients did not prove harmful

Brain Tumors - A chiasmatic pilocytic astrocytoma undergoes malignant transformation

Breast Calcifications - Primary osteosarcoma can occur in the breast

Breast Cancer - An extract of Nigerian Vernonia amygdalina is an active anticancer agent

Breast Cancer - Basement membrane invasion is preceded by type XV and XIX collagen loss

Breast Cancer - European studies highlight value of screening

Breast Cancer - Heregulin encourages the tumorigenicity and metastasis of breast cancer cells

Breast Cancer - MRI monitors breast tumors for the effectiveness of antiangiogenesis therapy

Breast Cancer - Race cited in gene study

Breast Cancer - Scientists identify molecular link between estrogen receptors and metastasis

Breast Imaging - Imaging simulated masses results in the lowest average glandular dose

Breast Tumor Suppression - Defects in TACC2 expression may contribute to the pathogenesis of some tumors

Cancer Chemotherapy - Capecitabine treatment results in increased volume of red blood cells

Cancer Gene Therapy - Preclinical drug studies accelerate understanding of MDA-7 gene functions

Cancer Gene Therapy - Study suggests company's gene product could play role in tumor reversion

Cancer Genomics - Tumors secrete factors and receptors that encourage endothelial cell mechanisms

Cancer Immunotherapy - Grant awarded for tumor growth inhibition research

Cancer Pain - Italy reforms national policy for cancer pain relief and opioids

Cancer Risk Factors - New study set to help women at high risk of breast or ovarian cancer

Cancer Spread - Thyroid and breast cancer are confined in their pattern of lymphatic spread

Cancer Suppressor Gene - Inactivation by methylation of the 3p21.3 gene BLU allows cancer growth

Cancer Therapies - New preclinical data released for novel liposomal drug formulations

Cancer Therapy - A novel attenuated replication-competent adenovirus causes melanoma regression

Cancer Therapy - An Ets-1 dominant-negative mutant disturbs normal and tumor angiogenesis

Cancer Therapy - Thioredoxin redox inhibitors staunch hypoxia-related tumor signals

Cancer Vaccine - Cancer patients experience tumor regression despite low T cell levels

Cancer Vaccine - Vaccines prolong survival of colorectal cancer patients

Cancer Vaccine - Variety of cancer vaccines available to combat malignancies

Candidiasis - Disseminated candidiasis in leukemia associated with IL4 promoter haplotypes

Carcinogenesis - Ceramides with acyl groups larger than C6 might act as tumor promoters

Cell Biology - 5-lipoxygenase in epithelial cells may contribute to diseases like cancer

Cell Biology - Bacterial enzyme reveals one key to cancer cell survival

Cell Biology - Research reveals the magic behind merlin

Cellular Hypoxia - The tumor associated CAIX is dependent on SP1 activity

Cervical Cancer - All-trans retinoic acid activates the p21WAF1 gene in squamous carcinoma cells

Cervical Cancer - Autofluorescence spectroscopy of malpighian epithelial cells may detect cancer

Cervical Cancer - Experts applaud FDA approval of new screening option

Cervical Cancer - Papilloma L2 facilitates infection by motifs reactive with host surface proteins

Cervical Cancer - Papillomavirus E6 requires E6AP to form a complex to degrade p53

Cervical Cancer - Screening is working well, but is labor-intensive

Cervical Cancer Risk Factor - More sensitive cervical cancer screening methods needed

Chemotherapy - Changes in family relationships affect chemotherapy-related nausea symptoms

Chemotherapy - Metronomic dosing with short intervals makes sense for reducing tumor burden

Chronic Myeloid Leukemia - Up-regulation of survivin may be involved in typical CML evolution

Colon Cancer Therapy - Subtractive immunization identifies a cell surface phosphorylated glycoprotein antigen

Colorectal Cancer - 5-FU, leucovorin, oxaliplatin combination in advanced colorectal cancer

Colorectal Cancer - Campaign focuses on regular screening

Colorectal Cancer - Colorectal carcinoma cells orient the secretion of stromal growth factors

Colorectal Cancer - CpG island methylation is a common finding in a genetic survey of cell lines

Colorectal Cancer - There may be an important role for HIP in colorectal cancer metastasis

Colorectal Carcinoma - 5-FU-induced peripheral neuropathy is a rare complication of well-known drug

Cutaneous T-cell Lymphoma - Certain cancer-germline genes are able to elicit systemic immune response

Dendritic Cell Vaccine - Advancements in dendritic cell vaccines for cancer therapy expected

Endocrinology - Estrogen-induced Ets-1 expression promotes capillary formation in tumors

Environmental Toxins - Women with breast cancer five times as likely to have pesticide (DDT) residues in their blood

Enzymology - The matrix metalloproteinase inhibitor MMI270 has antiangiogenic effects

Epstein-Barr Virus - Transmembrane domains 1 and 2 of LMP1 interact with the lipid raft

Erythroleukemia - Chromosomes have multiple rearrangements, with 3 breakpoints common to all

Exercise - Exercise improves body image in women being treated for breast cancer

Familial Melanoma - Metastatic and other patterns appear to be the same for all disease

Fatty Liver Disease - S-adenosylmethionine modulates proteins involved in steatohepatitis

Funding - Cancer diagnostics firm completes venture-backed financing round

GI Cancer - Colon cancers could be methylated from an early stage

GI Stromal Tumor - Complete remission of metastatic GI tumor can occur with imatinib treatment

GI Stromal Tumor - Rare GI stromal tumor can arise from the rectal mesentery

Gastric Cancer - Candidate tumor suppressor genes at FRA7G do not suppress malignancy

Gastroenterology - Circulating plasma factors may be predictors for gastric cancer metastasis

Gene Promotion - A novel reporter gene reveals pertinent information on noninvasive images

Gene Targeting - Overexpressed cell factors uphold therapeutic approaches to skin remodeling

Glioma - Platelet-derived growth factor-b promotes tumor growth through angiogenesis

Granuloma Annulare - Dermatological condition can also be due to Mycobacterium marinum infection

Gynecological Malignancy - Peritoneal involvement can be treated with docetaxel intraoperatively

HHV-8 - MALT lymphoma cells associated with Sjogren syndrome were beside infected cells

Health Care Conflicts - Alternative dispute resolution may avoid health care litigation

Hematological Oncology - Low-dose therapy improves anemia in myelofibrosis with myeloid metaplasia

Hematology - Conditioning irradiation induces radio-adaptive responses in stem cells

Hematology - Increased angiogenesis can be found in many hematological cancers

Hepatocellular Carcinoma - TMA-HPA assay is a convenient way to determine HBV recurrence after surgery

Hepatotoxin - Chlorophyllin prevents the toxic effects of aflatoxin exposure on the liver

Hodgkin Disease - Hemophagocytic syndrome could be the only clinical symptom

Human Papillomavirus - Phase II study results of vaccine combination released

Immunology - The interleukin-21 gene generates systemic immunity against colon cancer cells

Impaired Spermatogenesis - Higher Leydig cell micronodules and luteinizing and FSH appear responsible

Infection Burden - Early malignancy in developing world may relate to telomere shortening

Informed Consent - Information providers disclose may not comply with legal standards

Kidney Transplant Complication - Immunosuppression may cause uterine tumors in some recipients