Leukemia
Imatinib mesylate abates growth factor secretion in chronic myelogenous leukemia
Published in Cancer Weekly, May 13th, 2003
"A large and diverse spectrum of oncogenes has been implicated as a contributor to angiogenesis in solid tumors based, in part, on its ability to induce proangiogenic growth factors such as vascular endothelial growth factor (VEGF), and the fact that various antioncogenic signaling inhibitor drugs have been shown to reverse such proangiogenic effects both in vitro and in vivo." scientists in Canada report.
"Because leukemias are now also considered to be angiogenesis-dependent malignancies, we asked whether a similar paradigm might exist for the BCR-ABL oncogene and the...
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Source: Cancer Weekly (2003-05-13)
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