Virology

Serotype 3 knob substitution in serotype 5 adenovirus enhances its efficacy

Published in Cancer Weekly, May 13th, 2003

Serotype 3 knob substitution in serotype 5 adenovirus enhances its efficacy.

According to recent research published in the journal Cancer Research, "adenovirus (Ad) serotype 5 (Ad5) continues to be the predominant vector used for cancer gene therapy. However, many tumor types are reported to be relatively refractory to Ads infection because of low surface expression of the native Ads receptor, CAR. The observation that many tumor cells are CAR deficient has necessitated the development of CAR- independent infection strategies, including the introduction of heterologous ligand sequences into the virus fiber gene and immunological or chemical modifications of the...

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Source: Cancer Weekly (2003-05-13)

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