Cancer Weekly

Kidney Cancer - Scientists report discovery of cancer-causing gene in childhood kidney tumor

Oncogenes - Myc binds to 10% of all genes

Dietary Anticarcinogens - Curcumin has great potential for prevention and therapy of cancer

Immunology - Scientists develop colony of mice that fight off virulent cancer

Prostate Cancer - Metastatic disease common, deadly and costly, multicenter study shows

Therapy - The novel tubulin-binding agent ZD6126 seeks out vascular cells

Acute Lymphoblastic Leukemia - Stratification of patients by minimal residual disease results may be useful

Acute Myeloid Leukemia - Lower superoxide dismutase activity and radical generation may impact disease

Acute Myeloid Leukemia - Role of WT1 tumor suppressor in murine hematopoiesis studied

Adrenal Pseudocysts - The solid part of adrenal pseudocysts does not enhance on CT

Aleukemic Leukemia Cutis - Aleukemic leukemia cutis can present as a benign-appearing eruption

Angiogenesis - New scientific data disclosed on Neovastat

Anogenital Dermatology - Lichen sclerosus is an autoimmune disorder with increased risk for cancer

Antiangiogenesis - The EGR-1 corepressor NAB2 halts vascular endothelial growth factor induction

Anticancer Drugs - Quaternary ammonium-melphalan conjugate is a potential cartilage targeter

Anticancer Effect - Telomerase activity was decreased by RNA interference in cancer cells

Anticancer Foods - Compounds from cooked brussel sprouts bar induction of oxidative DNA damage

Antimutagenic Foods - Doenjang's active compounds are genistein and linoleic acid

Antitumor Activity - Bortezomib has demonstrated antitumor activity in a variety of tumor types

Apoptosis - Actinomycin D (Act D) induces time-and dose-dependent apoptosis in K562 cells

B-Cell Lymphoma - API2-MALT1 fusion may be causative abnormality unrelated to autoimmune disease

B-Cell Lymphoma - Large B-cell lymphoma is in remission after eradication of H. pylori

Bladder Cancer - DR4 polymorphism is associated with environmental exposure and bladder cancer

Bladder Cancer - Increasing DNA topoisomerase-II alpha correlates with increasing tumor grade

Brain Cancer - Microvascular proliferation in glioblastoma originates in tumor stroma

Brain Metastases - Pivotal phase III trial results released for RSR13

Brain Tumor Diagnostics - Proton magnetic resonance spectroscopy distinguishes brain tumor types well

Breast Cancer - Attachment experiences may play a role in cancer

Breast Cancer - Cyclooxygenase-2 is more highly expressed than in more benign breast diseases

Breast Cancer - Disease progression is associated with increased plasma TGF-beta1

Breast Cancer - Elucidating family history of breast cancer patients is important

Breast Cancer - Estrogen receptor beta isoforms vary, some are associated with disease

Breast Cancer - Genistein aglycone leads to tumor growth inhibition

Breast Cancer - MRI was more sensitive than FDG-PET in disclosing malignant breast tumors

Breast Cancer - Mutated TP53 gene status is associated with metastasis, anthracycline resistance

Breast Cancer - Mutations in the C/EBPD gene are relatively uncommon in human breast cancer

Breast Cancer - No link seen between breast cancer risk and antidepressants

Breast Cancer - Survivors not told about lymphedema side effect

Breast Cancer - Widespread morphoea occurs after radiotherapy for carcinoma of the breast

Breast Cancer Pathology - CCAAT/enhancer-binding protein beta may modulate breast cancer invasion

Breast Cancer Vaccine - Novel bacillus Calmette-Guerin-MUC1-based breast cancer vaccine developed

Bronchial Carcinoma - Treatment of bronchial carcinoma is best assessed by multidisciplinary approach

Cancer Cells - Membrane-type matrix metalloproteinases are elevated in gliomas

Cancer Detection - New approach to cancer screening targets three deadliest cancers

Cancer Diagnosis - Initiating a dialog is preferable to protecting patients from bad news

Cancer Genetics - Distinct profiles of major gene clusters are prominent in prostate cancer

Cancer Prevention - Animal and cell line studies have shown chemopreventive activity of tea

Cancer Therapy - Company reports positive results from evaluation of new solid tumor treatment

Cancer Therapy - Insoluble endostatin forms amyloids that are cytotoxic to neuroblastoma cells

Cancer Therapy - Patent broadens technology platform to deliver radioactivity to cancer cells

Cancer Therapy - Potential anticancer applications of Virulizin expanded

Cancer Therapy - Preclinical data: Panzem inhibits hypoxia inducible factor

Cancer Therapy - Preclinical study shows INGN 241 drug effective for ovarian cancer

Cancer Therapy - Researchers review value of anticancer antibodies

Cancer Therapy - Researchers use DNA chips to determine how leukemia cells respond to treatments

Cancer Therapy - Tetrakis((Trishydroxy-methyl)phosphine)gold(I) chloride has antitumor properties

Cancer Vaccine - Vaccines for acute lymphoblastic leukemia available

Cell Proliferation - Early growth response 1 is an upstream gatekeeper of the p53 tumor suppressor

Cerebellar Medulloblastoma - A primitive neuroectodermal tumor by histology had isochromosome 17q

Cervical Cancer - Staining for CD34 reveals the significance of heavy blood in cervical smears

Cervical Disease - Human papillomavirus viral load and HPV16 are associated with high grade lesions

Cervical Lesions - A subset of dysplastic cervical lesions are not detected by the Pap test

Cervical Lesions - Cervicography is more sensitive than PAP test in detecting inflammatory lesions

Cervical Neoplasia - Bacterial vaginosis is not associated with cervical intraepithelial neoplasia

Chemotherapy - A mathematical model may be useful for cisplatin dosing

Chemotherapy - Dosage regimen is optimized in cancer chemotherapy using a mathematical model

Chondrosarcoma Cells - mRNA splicing plays an important role in the regulation of FGFRs' function

Collaborations - Cancer product licensing agreement announced

Colon Cancer - New evidence links high-fiber diet with reduced risk

Colon Cancer - Physiological lysophosphatidic acid enhances colon carcinoma cell metastasis

Colon Cancer Screening - Virtual CT colonography is preferred by patients over conventional therapy

Colorectal Cancer - APC has multiple additional roles in colorectal carcinogenesis

Colorectal Cancer - Alkylphospholipids can open epithelial tight junctions reversibly

Colorectal Cancer - Disease management firm launches help program for chronically ill patients

Colorectal Cancer - The colon-contrast examination is safe and cost-effective

Colorectal Tumors - MRI is superior to CT in T-staging of rectal cancer and detecting recurrence

Cutaneous Lymphoma - Bexarotene causes severe central hypothyroidism

Cutaneous T-Cell Lymphoma - Treatment with extracorporeal photopheresis induces Fas-ligand expression

Dendritic Cell Vaccine - Tumor-derived TGF-beta reduces efficacy of dendritic cell/tumor fusion vaccine

Dermatology - New coalition launches crusade against skin cancer caused by sun exposure

Disease Susceptibility - Three single nucleotide polymorphisms within the NOTCH4 gene were found

Drug Delivery - Permeation peptides increase uptake with D chirality and specific sequences

Endometrial Cancer - Transition from hyperplasia was marked by loss of expression of MLH1 and PTEN

Enzymology - Faulty protein kinase C regulation thwarts calcium related cell differentiation

Epstein Barr Virus - T lymphocyte killing of EBV-infected cancer cells increases with E. coli enterotoxin

Estrogen Receptor - A new non-steroidal diphenylnaphthyl propylene ligand is antiestrogenic

Eyelid Tumors - Recurrent solitary reticulohistiocytoma should be considered

Fallopian Tube Cancer - A novel Q3034R BRCA2 germline mutation is identified

Fibrous Histiocytoma - Early radiation-induced malignant fibrous histiocytoma occurs in the oral cavity

Food Additives - Mitogenic stimuli substantially alter susceptibility to chemical carcinogenesis

Gastric Cancer - Work, salt intake, and the development of stomach cancer are associated

Generic Drugs - Lannett announces Levothyroxine marketing and distribution agreement

Genetic Engineering - Researchers develop cancer-resistant mice

Genetic Stability - Chromosomal stability involves ribosylation of centrosome proteins including p53

Genomic Instability - The phosphatidylinositol metabolic pathway may be linked to DNA repair

Germ Cell Tumors - Thoracotomies may be beneficial for managing postchemotherapy disease

Granuloma Annulare - No definite relationship was found between GA and malignant neoplasms

Head and Neck Cancer - The E1A-gene suppresses EGFR and induces apoptosis in squamous carcinoma cells

Head and Neck Cancer - The tumor suppressor gene ECRG2 has a bifunctional role in the esophagus

Hepatocellular Carcinoma - Liver transplantation recipients should be selected following different criteria

Hepatocellular Carcinoma - Underexpression of a new RhoGAP protein, the tumor suppressor DLC2, is found

Hepatology - A DNA chip has clinical applications in the analysis of liver diseases