Head and Neck Cancer
The tumor suppressor gene ECRG2 has a bifunctional role in the esophagus
Published in Cancer Weekly, May 20th, 2003
According to a study from Peoples Republic of China, "esophageal cancer related gene 2 (ECRG2) is a novel candidate of the tumor suppressor gene identified from human esophagus. To study the biological role of the ECRG2 gene, we performed a GAL4-based yeast two-hybrid screening of a human fetal liver cDNA library. Using the ECRG2 cDNA as bait, we identified nine putative clones as associated proteins."
"The interaction of ECRG2 and metallothionein 2A (MT2A) was confirmed by glutathione S-transferase pull-down assays in vitro and co-immunoprecipitation experiments in vivo. ECRG2...
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Source: Cancer Weekly (2003-05-20)
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