Nitric Oxide Cytotoxicity

iNOS-expressing brain tumor cells may protect themselves by overinducing SOD1

Published in Cancer Weekly, May 27th, 2003

iNOS-expressing brain tumor cells may protect themselves against NO cytotoxicity by overinducing SOD1.

"In this study, inducible nitric oxide synthase (iNOS) expression in a series of 158 human primary brain tumors was analyzed.

"To gain some insight into the biological significance of iNOS expression in tumor cells, comparative immunohistochemical analyses were employed to characterize the expression of iNOS, superoxide dismutase (SOD) proteins (SOD1 and SOD2), Ki-67 antigen (MIB-1) and p53 protein in these cells," investigators in Japan report.

"Sixteen (39.0%) of the 41 glioblastoma multiforme (GBM) specimens showed iNOS...

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Source: Cancer Weekly (2003-05-27)

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