Skin Cancer

NF-kappaB can program tissue-selective effects

Published in Cancer Weekly, May 27th, 2003

NF-kappaB can program tissue-selective effects.

"NF-kappaB regulates normal and pathological processes, including neoplasia, in a tissue-context-dependent manner," researchers in the United States report.

"In skin, NF-kappaB is implicated in epidermal homeostasis as well as in the pathogenesis of squamous cell carcinoma; however, its function in the underlying mesenchymal dermis has been unclear," wrote K. Hinata and colleagues, Stanford University School of Medicine.

"To gain insight into NF-kappaB roles in these two adjacent cutaneous tissue compartments, NF-kappaB effects on expression of 12 435 genes were determined in...

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Source: Cancer Weekly (2003-05-27)

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