Published in Cancer Weekly, May 27th, 2003
"NF-kappaB regulates normal and pathological processes, including neoplasia, in a tissue-context-dependent manner," researchers in the United States report.
"In skin, NF-kappaB is implicated in epidermal homeostasis as well as in the pathogenesis of squamous cell carcinoma; however, its function in the underlying mesenchymal dermis has been unclear," wrote K. Hinata and colleagues, Stanford University School of Medicine.
"To gain insight into NF-kappaB roles in these two adjacent cutaneous tissue compartments, NF-kappaB effects on expression of 12 435 genes were determined in...
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