Breast Cancer

Claudin-7 has role in progression, ability of breast cancer cells to disseminate

Published in Cancer Weekly, May 27th, 2003

Claudin-7 has a role in progression and ability of breast cancer cells to disseminate.

"Claudius are transmembrane proteins that seal tight junctions, and are critical for maintaining cell-to-cell adhesion in epithelial cell sheets. However, their role in cancer progression remains largely unexplored.

"Here, we report that Claudin-7 (CLDN-7) expression is lower in invasive ductal carcinomas (IDC) of the breast than in normal breast epithelium, as determined by both RT-PCR (9/10) and Western analysis (6/8)," scientists writing in the journal Oncogene report.

"Immunohistochemical (IHC) analysis of ductal carcinoma in situ...

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Source: Cancer Weekly (2003-05-27)

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