B Cell Leukemia

Vitamin D3 analog EB1089 effectively induces p53-independent apoptosis

Published in Cancer Weekly, May 27th, 2003

The vitamin D3 analog EB1089 is highly active against B-cell chronic lymphocytic leukemia cells in vitro.

"EB1089, a novel vitamin D3 analog, has been shown to have cytotoxic and antiproliferative properties in a variety of malignant cells. However, its potential as a treatment for B-cell chronic lymphocytic leukemia (B-CLL) has not been evaluated.

"EB1089 induced apoptosis in all of the 102 B-CLL samples tested with a mean LD50 value (the concentration of EB1089 required to kill 50% of cells ± SD) of 21 x 10^-8M ±1.4 x 10^-8M," scientists writing in the journal Blood report.

"Furthermore,...

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Source: Cancer Weekly (2003-05-27)

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