Endocrinology

MZ-4-71 inhibits murine endothelial cell angiogenic secretion and proliferation

Published in Cancer Weekly, May 27th, 2003

MZ-4-71 inhibits murine endothelial cell angiogenic secretion and proliferation.

"Angiogenesis plays a key role in solid tumor formation, invasiveness and metastasis. Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen that is necessary in the process of neovascularization. Antagonists of growth hormone-releasing hormone (GH-RH) have been shown to suppress both in vivo and in vitro growth and metastasis of many human cancer cell lines," researchers in Poland report.

"The mechanisms that mediate the antitumorigenic actions of these antagonists involve direct and indirect pathways, but are not completely elucidated. We...

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Source: Cancer Weekly (2003-05-27)

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