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Cancer Weekly

Susan Hasty, Publisher

Table of Contents . . . June 3rd, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Cancer Weekly | Other Publications

Ovarian Cancer - Tumor cell sensitivity - then resistance - to chemotherapy linked to gene

Pancreatic Cancer - Scientists uncover role of Fanconi anemia genes

Breast Cancer - Lower survival for black women under 50 may be due to differences in treatments

Cancer Therapy - Cell migration is the object of vascular targeting by combretastatin A-4

Colon Cancer - High-calorie diet seems to increase chances of surviving longer

Prostate Cancer - Radioactive seed implantation safe and effective as alternative to surgery

Acute Lymphoblastic Leukemia - Gene dosage aids detection of 9p21 deletions in children

Acute Lymphoblastic Leukemia - Intensified GVHD prophylaxis enables haploidentical stem cell transplants

Allergy-Cancer Associations - Dust mite allergy increases the risk of prostate cancer

Aplastic Anemia - Antithymocyte globulin and cyclosporine can lead to Merkel cell carcinoma

Asbestos Toxicity - Ascorbic acid modifies the surface of asbestos, removing iron and silica

B Cells - Dexamethasone and anti-IgM apoptosis will not occur if Ik-6 is overexpressed

Bleeding Disorder - Acquired von Willebrand syndrome occurs in some geriatric patients

Bone Marrow Transplant - Lymphoproliferative disorder can have EBV infection in both B and T cells

Breast Cancer - 1100delC may be the only CHEK2 allele that contributes to breast cancer

Breast Cancer - Absorption and metabolism determined the tissue pharmacokinetics of capecitabine

Breast Cancer - Biological markers or lack thereof are predictive of clinical recurrence

Breast Cancer - Molecular analysis of early lesions may be key to choosing best treatment

Breast Cancer - Other active and safer SERMs and aromatase inhibitors need to be developed

Breast Cancer - Overexpression of KCNK9 in cell lines promotes tumor formation

Breast Cancer - Sentinel lymph node biopsy is accurate for staging

Breast Cancer - Tissue bank lowers cost of materials

Breast Cancer Screening - Mammograms read by specialists save patients' time and money

Cancer Epigenetics - DNA methylation markers are promising future tools in the clinic

Cancer Immunotherapy - TNF-alpha production induced from human monocytes by beta-1,3-glucan oligomer

Cancer Mortality - Cancer now No. 1 cause of death in U.K. men

Cancer Prognosis - Vascular growth factor predicts recurrence in liver cancer patients

Cancer Therapy - Homocysteine is a strong suppressor of human tumor cell gelatinases

Cancer Therapy - Permission given to initiate LEP-ETU clinical trial

Cancer Vaccine - Antibody mimic CO17-1A elicits immune response in colorectal cancer patients

Cancer Vaccine - Costimulatory molecule vaccine effective against B-cell lymphoma in mice

Chronic Myelogenous Leukemia - Oncogene-expressing stem cells downregulate tumor suppressor BRCA1

Colon Cancer - First results released from largest diet-cancer study ever undertaken

Colon Cancer - PET scans are superior to CT scans for detecting metastasis

Colon Cancer - p53 Protein is a mechanism of resistance to amifostine-induced apoptosis

Colonoscopy - MR colonoscopy is noninvasive, safe, and highly accurate

Colorectal Cancer - Ets-1 marks angiogenic potential and prognosis in colorectal carcinomas

Colorectal Cancer - Increased dysadherin expression lowers patient survival

Colorectal Cancer - S-1 active in advanced colorectal cancer

Colorectal Cancer - Significant public misconceptions persist about cancer screening

DNA Vaccine - Lipopolysaccharide not needed for T-cell response to DNA vaccination

Dermatology - A novel integrin antagonist induces apoptosis in angiogenic endothelial cells

Dyskeratosis Congenita - Dyskeratosis congenita is associated with three malignancies many years later

Endometrial Cancer - Gene mutation in some uterine tumors may signal that cancer runs in family

Esophageal Carcinoma - Radiotherapy may be a treatment of choice for liver metastasis

Fetal Nephroblastoma - Bilateral fetal rhabdomyomatous nephroblastoma occurs in a 10-month-old baby

Fine Needle Aspirates - KOC is a novel molecular indicator of malignancy

Gastric Cancer - CA 72-4 antigen can be considered the marker of choice in patient follow-up

Gynecology - Lysophosphatidic acid is an angiogenic mediator in ovarian cancer

Head and Neck Cancer - Multiple assays confirm esophageal cancer rib marrow micrometastasis

Hearing Loss - Bilateral irreversible hearing loss is associated with chemotherapy

Helicobacter Pylori - The virulence gene cagA and MUC2 mucin are linked with cancer risk

Hepatic Carcinoma - Tube cholangio-jejunal bypass performed in unresectable hepatic hilar carcinoma

Hepatobiliary Cancer - Homozygous deletion scanning reveals alternative pathways for carcinogenesis

Hepatocellular Carcinoma - Enhanced specific gene expression is a new strategy for treating liver cancer

Hepatocellular Carcinoma - Hemolysis and hemoglobinuria occur during radiofrequency ablation of liver tumor

Hepatocellular Carcinoma - Macrophage inflammatory protein marks a therapy's efficacy against liver cancer

Human Papillomavirus - Strong association seen between penile SCC and the presence of HPV DNA

Imaging - Image-enhancing tool could improve cancer diagnosis and treatment

Imaging - MDCT shows promise in detecting urinary tract cancers

Imaging Technology - Technique developed for serial in vivo imaging of antigen-specific T cells

Immune Therapy - Cutaneous B-cell pseudolymphoma is a recurrent risk years after antigen therapy

Inflammation - Lipoxins work towards resolution of intestinal and other inflammations

Kidney Cancer - Extreme heat effective for treatment

Leukemia - Acute myeloid leukemia can be associated with necrotizing temporal arteritis

Leukemia - Dexamethasone induced leukemic cell apoptosis and decreased cell count

Leukemia - Johnson & Johnson awards $180,000 grant for drug research

Leukemia - MOZ gain of function contributes to leukemogenesis

Leukemia - Magnolol induces apoptosis in human leukemia cells

Leukemia - PTEN protein may be absent in B-CLL with a normal PTEN genotype

Liver Cancer - Primary liver cancer treated successfully by chemoembolization and radiotherapy

Liver Surgery - Percentage of liver remaining is predictive of degree of hepatic function

Low-Frequency Magnetism - Coexposure with magnetic fields and vinblastine increases effect on lymphocytes

Lung Cancer - Iressa approved by FDA

Lung Cancer - Uteroglobin transduction has an inhibitory effect on lung cancer cell lines

Lymphoma - 11778 Mutation does not change cellular response to cytotoxic drugs

Lymphoma - HCV infections are detected in many people with primary lymphoma of the liver

Lymphoma - Maintenance regimens directed towards cyclin D1 may inhibit some malignancies

Lymphoma - Rituximab given with chemotherapy results in higher rates of complete response

Malignant Glioma - Enrollment has resumed in phase I glioma study

Malignant Meningioma - Doxil induces regression of pleuropulmonary metastases from malignant meningioma

Micrometastasis - Real-time PCR provides for quantitative detection of gastric cancer metastasis

Model Development - Angiogenic cytokine production in human tumor xenografts is site dependent

Multiple Myeloma - FDA approves Velcade treatment

Nasopharyngeal Carcinoma - Hypericin-mediated photodynamic therapy shrinks tumors in mouse model

Neuroblastoma - Immune cells may help deliver cancer vaccines for children

Neuroscience - Gene expression profiling produces prospective targets for glioblastoma therapy

Non-Hodgkin Lymphoma - CBV conditioning for stem cell transplantation safe and effective

Occupational Disease - EMF exposure increases prostate cancer mortality in electric utility workers

Occupational Health - Vinyl chloride monomer exposure compounds the effects of hepatitis B virus

Oncogenesis - Hepatitis C virus-related liver cancer can prevail where hepatitis B is endemic

Oncology - Communication is a core clinical skill in oncology

Oncology - Conjugated linoleic acid decreases growth factor-induced angiogenesis

Oncology - Distorted growth factor signals accelerate liver cancer malignant potential

Oncology - Thymidine phosphorylase signals control the angiogenesis of ovarian cancer

Ovarian Cancer - FDA approves enhanced labeling for liquid-based cytology

Ovarian Cancer - Patients want improved communication about sexual issues

Ovarian Carcinosarcoma - Carcinosarcoma of the ovary is a rare yet aggressive variant

Pancreatic Cancer - Activity level and body weight not predictive of pancreatic cancer mortality

Pancreatic Lymphoma - Endoscopic ultrasonography is very useful in follow-up after treatment

Pancreatic Tumors - ESD is useful both for treating and for diagnosing pancreatic lesions

Papillary Cancer - Autofluorescence endoscopy images pancreatic cancer as dark red

Pediatric Cancer - Hyperthyroidism is a rare complication of head and neck irradiation

Pediatric Pulmonary Carcinoid - Tumor resection generally results in good prognosis

Pelvic Tumors - Most pelvic tumors in adolescents should have multidisciplinary treatment

Photodynamic Therapy - Nanoparticles improve the efficacy of porphyrin in mammary tumors

Prostate Cancer - Adenovirus-based FasL expression produces bystander killing in local cells

Prostate Cancer - Biomagnetic measurements differentiate cancer from benign prostate hyperplasia

Prostate Cancer - Data are reduced using a discrete wavelet transform

Prostate Cancer - Tool developed to help men pick the best place for treatment

Proteomics - Progress in immunoconjugate technology has revitalized the magic bullet concept

Psoriasis - The S100A7 or psoriasin gene is duplicated 5 times in humans

Rectal Cancer - Alcohol increases risk, but risk is smaller among regular wine drinkers

Sarcoma - Combinatorial IL-12 and IL-18 gene therapy strikes out at distant tumors

Selective Transfection - ONYX-015 is deemed safe for patients with recurrent cancer

Skin Cancer Risk Factor - People obtain only 25% of lifetime UV exposure by age 18

Skin Cancer Therapy - Boron target compounds assessed for boron neutron capture therapy

Smoking - Parents who quit when kids are young cut chances of kids becoming teen smokers

Stem Cell Research - Patented stem cell expansion technology acquired

Stem Cell Transplantation - Feto-maternal microchimerism prevents T-cell reactions

Stem Cell Transplantation - Single leukapheresis should be used for pediatric solid tumor patients

Stem Cell Transplantation - Treatment effective for t(8;13)-related myeloproliferative disorder

Testicular Cancer - Contrast agent assists in accurate detection of lymph node disease

Transplant Medicine - Chronic graft-versus-host disease improves outcome against multiple myeloma best

Tumor Ablation - RITA receives FDA clearance for new Side-Deployment Electrode

Vector Development - Endothelial progenitor-like cells are angiogenesis-selective gene vectors

Virology - Apoptotic signals in hepatitis C virus infection are contradictory

Virology - Hepatitis C virus IRES facilitates protein synthesis in tumor vessels

Vocal Fold Paralysis - Laryngeal electromyography can determine the pattern of nerve injury

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