Cancer Weekly

Colorectal Cancer - Vaccine trial launched for previously untreated metastatic disease

Gene Profiling - Genomic tools identify profiles of gene activity underlying cancer

Breast Cancer - Scientists return to rat as biomedical research tool

Cancer Risk Factor - Obesity increases cancer mortality

Drug Delivery - Research suggests strategies for getting drugs to cancer cells

Gene Recombination - A new fusion gene uses vaccine mechanisms to halt kidney cancer

AIDS - Vaccine to be developed will be directed against multiple HIV antigens

Acute Myeloid Leukemia - Flow cytometric assay detects apoptosis proteins in residual tumor cells

Adenoid Cystic Carcinoma - Radiotherapy is effective in primitive intracranial adenoid cystic carcinoma

Anorectal Melanoma - Radical surgery benefits patients with large yet localized disease

Antiangiogenesis - Several stumbling blocks are likely to slow clinical use of anti-VEGF therapy

Anticancer Agents - Chemical genomics strategy can aid in the discovery of new anticancer agents

Bone Cancer - CAR expression makes adenovirus-based therapy viable for osteosarcoma patients

Breast Cancer - ASCO assesses updated trial results on Arimidex use for early breast cancer

Breast Cancer - Breast Cancer Foundation grant benefits San Deigo women under 40

Breast Cancer - Frozen section telepathology had a mean diagnosis time of 15 minutes

Breast Cancer - Genetic testing feedback should be given only when there are specific reasons

Breast Cancer - Inactivation of MMR genes is responsible for MSI in breast cancer cell lines

Breast Cancer - Maspin mRNA has prognostic value in postmenopausal breast carcinomas

Breast Cancer - Mayo Clinic will lead national research study to search for molecular predictors

Breast Cancer - Racial differences remain in stage at diagnosis, survival

Breast Cancer - The CYP3A4*1B variant is related to the onset of puberty

Breast Cancer - University of Michigan agrees to licensing of mammastatin technology

Breast Cancer Screening - Cancer Society endorses mammograms, moves away from self-exams

Breast Carcinoma - Bi-213-PAI2 shows promise in preclinical studies of metastatic cancers

Brest Cancer - There is remarkable genetic complexity and heterogeneity in human breast cancer

CNS Neoplasms - Researchers isolate the first fusion RTK protein from a human astrocytoma

Cancer Diagnostics - MRI-guided breast biopsy device can hasten early cancer detection

Cancer Gene Expression - Lynx announces extension of prostate cancer study

Cancer Guidelines - Anemia practice guidelines provide direction on dosing of erythropoietic agents

Cancer Metastasis - Early-stage peritoneal micrometastatic tumors are more vulnerable to therapy

Cancer Metastasis - Intratumoral lymphatics are essential for head and neck cancer dissemination

Cancer Metastasis - Nitric oxide regulates tumor-cell survival and influences cancer metastasis

Cancer Recurrence - Placenta growth factor is linked to recurrent cancers in humans

Cancer Risk - Early toxic effects in marine life predicted later risks for cancer in divers

Cancer Risk - The risk of Hodgkin disease may be associated with exposure to infections

Cancer Risk Factors - Pro-vitamin supplement may increase risk in smokers and drinkers

Cancer Therapy - Alpha integrins foster antiangiogenic properties of tumstatin and endostatin

Cancer Therapy - Article looks at Onconase and its therapeutic potential

Cancer Therapy - Clinical development program reports progress

Cancer Therapy - The SIM2 Down's syndrome gene is a drug therapy target for solid tumors

Cancer Vaccine - Hydroxynorleucine used to introduce amino acid group into carbohydrates

Cancer Vaccine - Interleukin 12 is promising adjuvant for cancer vaccination

Cancer Vaccine - Progenipoietin plus melanoma tumor antigen vaccine stimulates immune response

Cancer Vaccine - Removing CD4+ T cells overcomes suppression of anti-HER2 immune responses

Cancer Vaccine - Therapeutic vaccine effective against EBV-associated cancers

Cardiac Tumor - Primary adenocarcinoma of the left atrium mimics a benign myxoma

Cervical Neoplasia - HPV status was not associated with the clinical outcome of cervical neoplasia

Chemotherapy - Inflammatory response identifies patients with more aggressive disease

Childhood Illness - Post-traumatic stress disorder can affect children with life-threatening illness

Chronic Hepatitis B - A decline in alpha-fetoprotein may signal lamivudine-induced stability

Chronic Myeloid Leukemia - FDA approves Gleevec for pediatric leukemia treatment

Chronic Myeloid Leukemia - ST1571 effective for relapsed patients with advanced disease

Clinical Trials - Clinical research participation by community oncologists is low

Collaborations - Genedata enters collaboration on proteomics-based cancer diagnostics

Colon Cancer - Drug shows some good results

Colon Cancer - Gen-17.1A significantly inhibited colon cancer cell growth in vitro and in vivo

Colon Cancer - HIF-l alpha is associated with tumor vascularization in colorectal carcinoma

Colon Cancer - Small interfering RNAs directed against beta-catenin inhibit cancer cell growth

Colon Carcinoma - Colonic epithelial cell apoptosis is induced p47-dependent oxidants

Colon Carcinoma - Mesalazine may be a chemopreventive agent for colorectal cancer

Colorectal Cancer - Frequency recommendations for sigmoidoscopy screening may be too aggressive

Colorectal Cancer - Mortality higher in African Americans residing in Appalachia

Colorectal Cancer - Nonsteroidal anti-inflammatory drugs reduced the rates of adenomas

DNA Damage - Arsenite-induced NO generation is cell-cycle- and NBS1-dependent

DNA Damage - The ASPP family of proteins directs cells toward death after p53 upregulation

Dendritic Cell Vaccine - Host absence of CCR5 potentiates dendritic cell vaccination

Depression - Appetite changes may indicate disorder in cancer patients

Desmoid Tumors - Desmoid tumors occur in a scar from radical nephrectomy for renal cancer

Diagnostics - New biopsy system may reduce need for open surgical biopsy

Diagnostics - New group to focus on cancer diagnostics

Drug Resistance - Cancer outwitted by chemical flank attack

Enzymology - Serum matrix metalloproteinase is clinically significant in some liver diseases

Finance - Pharmaceutical company announces 2003 first quarter results

Finance - iCAD patent lawsuit dismissed, company reports first quarter results

Gangliocytic Paraganglioma - Infiltrative pattern of gangliocytic paraganglioma shows neoplastic nature

Gastroenterology - FDA clears new, noninvasive colonography technology

Gastroenterology - Urokinase-type plasminogen activator foretells poor outcomes in gastric cancer

Generic Drugs - FDA acceptance of ciprofloxacin ANDA filing triggers strategic investment

Glioblastoma - Genetically engineered virus causes total regression of deadly brain cancer

Glioblastoma - Vascular endothelial growth factor overexpression drives brain cancer growth