Published in Cancer Weekly, June 10th, 2003
According to a study from the United States, "The BCL6 proto-oncogene encodes a transcriptional repressor whose expression is deregulated by chromosomal translocations in approximately 40% of diffuse large B-cell lymphomas (DLBCLs).
"The BCL6 regulatory sequences are also targeted by somatic hypermutation in germinal center (GC) B cells and in a fraction of all W-derived lymphomas. However, the functional consequences of these mutations are unknown," wrote L. Pasqualucci and colleagues, Columbia University, Institute of Cancer Genetics.
"Here we report that a subset of mutations...
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