Cancer Therapy
Alpha integrins foster antiangiogenic properties of tumstatin and endostatin
Published in Cancer Weekly, June 10th, 2003
"Tumstatin and endostatin are two inhibitors of angiogenesis derived from precursor human collagen molecules known as alpha3 chain of type IV collagen and alpha1 chain of type XVIII collagen, respectively. Although both these inhibitors are noncollagenous (NC1) domain fragments of collagens, they only share a 14% amino acid homology. In the present study we evaluated the functional receptors, mechanism of action, and intracellular signaling induced by these two collagen-derived inhibitors," scientists in the United States reported.
"Human tumstatin prevents angiogenesis...
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Source: Cancer Weekly (2003-06-10)
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