Dendritic Cell Vaccine
Host absence of CCR5 potentiates dendritic cell vaccination
Published in Cancer Weekly, June 10th, 2003
According to a study from the United States, "Previous work has shown that dendritic cells (DCs) express specific chemokine receptors that allow for coordinated movement in vivo. To test the in vivo relevance of this, we used a murine melanoma system and knockout mice to investigate the function of the chemokine receptor CCR5 and its ligands, CCR ligand (CCL)3 and CCL5. We found that the lack of CCR5 in the host mouse resulted in delayed tumor growth, but this effect was overcome at a higher tumor load."
"With the administration of tumor charged DCs, CCR5-/- mice that had...
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Source: Cancer Weekly (2003-06-10)
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