Cancer Weekly

Cancer Therapy - Use of microorganisms for treating cancer

Melanoma - Study offers hope for first new treatment in decades

Acute Myocardial Infarction - Breast cancer survivors have a lower risk for heart attacks

Brain Cancer - Neomycin cripples the invasive capacity of glioma

Imaging - 'Virtual biopsy' offers a new way to look at cancer

Photomedicine - Pharmacokinetics of photodynamic therapy agent determined in cancer patients

Acute Lymphoblastic Leukemia - Rituximab with stem cell autografts effective after relapse

Adenocarcinoma - Papillary serous adenocarcinoma was less likely to express vimentin

Alcohol Consumption - Hepatocarcinogenesis may be enhanced by chronic, but not transient use

Angiogenesis - Company compares antiangiogenesis VEGF antibodies

Anticancer Therapy - Regulatory RNA: B16 RNA provides antimelanoma activity, upregulating NF-kappa B

Antineoplastic Drugs - Validated pharmacogenomic biomarkers may help select optimal treatment regimens

Antitumor Drug Response - PAOh1 in combination with SSAT, may be exploited for therapeutic advantage

Antitumor Drugs - PI3K-Akt has been shown to be the target of various antitumor drugs

Apoptosis Mechanisms - Promyelocytic leukemia protein stimulates TNFalpha induced apoptosis

Basal Cell Carcinoma - Hh inhibitors could be a valid therapeutic approach for treating BCC

Biochemistry - Sef inhibits fibroblast growth factor signaling on at least two levels

Biochemistry - p53 and TGF-beta gene tumor suppressor pathways linked, study shows

Biomarkers - Angiopoietin-like 4 could be a diagnostic tool and target in several disorders

Blood Substitutes - Recombinant HSA incorporating synthetic heme reoxygenates hypoxic solid tumor

Bloom Syndrome - Increased cancer risk and BLMAsh mutation are not related

Bone Infection - Aspergillus EIA test kit receives FDA 510(k) clearance

Bone Marrow Transplantation - Targeted intervention before transplantation may improve quality of life

Brain Tumor - Diallyl disulfide inhibits the expression of H-ras in rat brain C6 gliomas

Brain Tumor - Perfusion-weighted MR can evaluate cerebral perfusion in peritumoral brain edema

Brain Tumor - SCH58500 provides measurable efficacy in preclinical brain tumor models

Brain Tumor - Symptomatic residual subependymoma tumors require close observation

Brain Tumors - MRI in mice can visualize placement of an intracerebral drug delivery system

Breast Cancer - Akt may be a target for enhancing radiotherapy response

Breast Cancer - Hormone replacement therapy after diagnosis may not be contraindicated

Breast Cancer - PPAR gamma ligands and ATRA inhibit the invasion of breast cancer cells in vitro

Breast Cancer - PathVysion gene test gaining ground as standard diagnostic

Breast Cancer - Physical exercise reduces risk of breast cancer in Japanese women

Breast Cancer - Positive results reported for ABI-007

Breast Cancer - Psoriasin interacts with Jab1 and influences breast cancer progression

Breast Cancer - Psychological intervention should be geared to different age groups

Breast Cancer - Quick MRI-guided biopsy now an option

Breast Cancer - Review: High-dose chemotherapy in metastatic breast cancer

Breast Cancer - Tumors that produce cyclooxygenase-2 are linked to poor prognosis

Breast Cancer Screening - FDA clears expanded size offering of mammosite device

Breast Cancer Screening - Radiology residents say 'no' to mammography

C-Reactive Protein - Expression in squamous cell esophageal cancer may indicate bad prognosis

Cancer Care - Private/public partnership bring affordable care to Hong Kong

Cancer Cell Lines - The collagen alpha2(I) gene is methylated in multiple cancer cell lines

Cancer Drugs - U.S. patent issued for new formulations of anticancer drug

Cancer Immunotherapy - Cytokine gene therapy combinations could become viable anticancer agents

Cancer Pathogenesis - Abnormal regulation of TGF-beta encourages tumor proliferation

Cancer Proteomics - The cinnamaldehyde derivative CB403 staunches mitosis to kill cancer cells

Cancer Research - A novel rodent model is predicted to advance the study of human breast cancers

Cancer Therapy - 2-Methoxyestradiol blocks tumor growth and angiogenesis by disrupting HIF-1

Cancer Therapy - Anticancer drug GTI-2501 advances into phase II clinical trial

Cancer Therapy - New hope seen for 'antisense' treatments

Cancer Therapy - Oncolytics announces issuance of seventh U.S. patent

Cancer Therapy - Safety phase of Lactoferrin trial completed

Cancer Vaccine - Allovectin-7 shows promise against metastatic melanoma

Cancer Vaccine - Antigen silencing in melanomas induced by oncostatin M

Cancer Vaccine - CTLA-4 antibody blockade increases tumor immunity in cancer patients

Cancer Vaccine - RNA-binding protein L523S is potential therapeutic target for lung cancer

Cancer Vaccine - Tumor-derived ER chaperone grp170 reduces pulmonary metastatic disease

Cancer Vaccine - Xenogenized vaccine cells persist in vivo, preventing tumor attack

Carcinogenesis - Calorie limits and diet makeup modulate tumorigenesis by different mechanisms

Carcinogenesis - Inflammation should be treated appropriately for chemoprevention of cancers

Carcinogenesis - Soluble nickel is associated with cancer risk in nickel refiner workers

Cervical Cancer - Gene overexpression increased from low- to high-grade lesions to cancer

Chemotherapy - CEP-6800 could be used as a chemopotentiating agent

Chemotherapy Potentiator - PSK increases docetaxel apoptosis, may be useful for treating pancreatic cancer

Chronic Myeloid Leukemia - Liver grafts can reverse relapse after bone marrow transplantation

Colon Cancer - Butyrate and bile acids have proapoptotic, antiapoptic effects on colon cancer

Colon Carcinoma - Inhibition of HDAC is an early event in cells treated with CI-994

Colon Tumors - AC-7700 has the potential to be useful in combination chemotherapy with CDDP

Colorectal Cancer - Systemic coagulation reactivation is observed in recurrence of colorectal cancer

Colorectal Cancer Screening - New test for cancer screen available

Corporate Update - Patent application filed for drug targeting SARS; distribution agreement for cancer drug signed

Death Ligands - FLIP and BCL-XL expression may reduce sensitivity of cancer cells to therapies

Dendritic Cell Vaccine - Transforming growth factor beta inhibits action of dendritic cell vaccines

Emergency Surgery - Neuroendocrine carcinoma of the ovary may manifest as a perforated intestine

Endometrial Carcinoma - Progesterone may be involved in regulation of beta-catenin expression

Endometrial Polyps - Breast cancer metastasized to tamoxifen-associated endometrial polyps

Enzymology - Serine proteases have complex roles in the staging of tumor angiogenesis

Epstein-Barr Virus - All B-lymphocyte subpopulations are equally susceptible to infection

Erythema Nodosum Leprosum - Data on Thalomid presented at workshop

Esophageal Cancer - Selenium may inhibit cancer progression in patients with Barrett esophagus