Osteosarcoma
No detectable TMM may identify a favorable clinical subset of patients
Published in Cancer Weekly, June 17th, 2003
"There are two telomere maintenance mechanisms (TMMs) in human tumors, telomerase activation (TA) and, more rarely, the process termed alternative lengthening of telomeres (ALT)," scientists in the United States report.
"Unlike most carcinomas, sarcomas, including osteosarcomas (OS), have been reported to display TA and ALT in more balanced proportions and, thus, present an opportunity to examine the impact of different TMMs on clinical tumor behavior.
"We studied OS samples from 62 patients for molecular evidence of TA and ALT," wrote G.A. Ulaner and...
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Source: Cancer Weekly (2003-06-17)
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