Cancer Pathogenesis
Abnormal regulation of TGF-beta encourages tumor proliferation
Published in Cancer Weekly, June 17th, 2003
According to published research from Japan, "transforming growth factor-beta (TGF-beta) is a potent growth inhibitor of most types of cells; therefore, perturbations of TGF-beta signaling are believed to result in progression of various tumors. On the other hand, TGF-beta has been shown to act as an oncogenic cytokine through induction of extracellular matrices, angiogenesis, and immune suppression."
"A wide variety of effects of TGF-P are mediated by physical interaction of signal transducer Smad proteins with various transcription factors," Miyazono and colleagues, University of Tokyo,...
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Source: Cancer Weekly (2003-06-17)
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